Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 12/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991899 | 0.82 | LMNA (0.56) | MAPTALDH1A1PKMSMN1; SMN2NPSR1 | |
| SCHEMBL85605 | 0.81 | MAPT (0.45) | MAPTALDH1A1PKMSMN1; SMN2NPSR1 | |
| SCHEMBL19180121 | 0.81 | MAPT (0.65) | MAPTALDH1A1PKMSMN1; SMN2NPSR1 | |
| SCHEMBL2945030 | 0.81 | HPGD (0.53) | MAPTALDH1A1L3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL6687266 | 0.81 | MAPT (0.64) | MAPTALDH1A1L3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL3551807 | 0.81 | PIK3CD (0.50) | PIK3CDMAPTSMN1; SMN2F10PTGS2 | |
| SCHEMBL18631038 | 0.79 | MAPT (0.47) | MAPTALDH1A1L3MBTL1PKMSMN1; SMN2 | |
| SCHEMBL28866946 | 0.78 | MAPT (0.49) | MAPTALDH1A1L3MBTL1HTTMAPK1 | |
| SCHEMBL30184634 | 0.78 | LMNA (0.57) | MAPTALDH1A1PKMSMN1; SMN2F10 | |
| SCHEMBL29212318 | 0.78 | LMNA (0.57) | MAPTALDH1A1PKMSMN1; SMN2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101300252-B | Novel cycloalkane carboxamides as factor Xa inhibitors | HOFFMANN LA ROCHE | 2011-09-28 | — | — | CN | disclosed |
| US-7678917-B2 | Factor Xa inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678917-B2 | Factor Xa inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7601752-B2 | Pyrrolidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-10-13 | — | — | US | disclosed |
| CN-101309919-A | Novel pyrrolidine derivatives as inhibitors of coagulation factor XA | HOFFMANN LA ROCHE (CH) | 2008-11-19 | — | — | CN | disclosed |
| CN-101300252-A | Novel cycloalkane carboxamides as factor Xa inhibitors | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | CN | disclosed |
| EP-1951717-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR XA | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-06 | — | — | EP | disclosed |
| EP-1928864-A1 | NOVEL CYCLOALKANE CARBOXAMIDES AS FACTOR XA INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007057317-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR XA | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-24 | — | — | WO | disclosed |
| US-20070112001-A1 | Pyrrolidine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-05-17 | — | — | US | disclosed |
| WO-2007025949-A1 | NOVEL CYCLOALKANE CARBOXAMIDES AS FACTOR XA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007025949-A1 | NOVEL CYCLOALKANE CARBOXAMIDES AS FACTOR XA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049587-A1 | Factor Xa inhibitors | HOFFMANN-LA ROCHE INC. | 2007-03-01 | — | — | US | disclosed |
| US-20070049587-A1 | Factor Xa inhibitors | HOFFMANN-LA ROCHE INC. | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049587-A1 | Factor Xa inhibitors | F12, F11, F10 | PIK3CD 3657/4885MAPT 4834/4885ALDH1A1 2585/4885 |
| US-20070112001-A1 | Pyrrolidine derivatives | F12, F2, F11 | PIK3CD 3583/4885MAPT 4845/4885ALDH1A1 1872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.