Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | F10 | P00742 | 4/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4638732 | 0.89 | PIK3CD (0.43) | PIK3CDF10PTGS2HTR1APIK3CA | |
| SCHEMBL4639953 | 0.83 | PIK3CD (0.46) | PIK3CDF10PTGS2HTR1A | |
| SCHEMBL991941 | 0.82 | F10 (0.51) | PIK3CDF10PTGS2PIK3CAPIK3CB | |
| SCHEMBL3547660 | 0.81 | PIK3CD (0.44) | PIK3CDF10PTGS2HTR1AKDM4E | |
| SCHEMBL2996200 | 0.78 | PTGS2 (0.50) | PIK3CDF10PTGS2PIK3CAPIK3CB | |
| SCHEMBL1028503 | 0.78 | F10 (0.48) | PIK3CDF10PTGS2PIK3CAPIK3CB | |
| SCHEMBL31347248 | 0.78 | F10 (0.48) | PIK3CDF10PTGS2PIK3CAPIK3CB | |
| SCHEMBL19178457 | 0.78 | F10 (0.51) | PIK3CDF10PTGS2PIK3CAPIK3CB | |
| SCHEMBL2450403 | 0.78 | MAPT (0.63) | PIK3CDTBK1KDM4ENSD2LMNA | |
| SCHEMBL2941206 | 0.78 | F10 (0.50) | PIK3CDF10PTGS2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951717-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR XA | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-06 | — | — | EP | claimed |
| WO-2007057317-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR XA | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-24 | — | — | WO | claimed |
| CN-101300252-B | Novel cycloalkane carboxamides as factor Xa inhibitors | HOFFMANN LA ROCHE | 2011-09-28 | — | — | CN | disclosed |
| US-7678917-B2 | Factor Xa inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678917-B2 | Factor Xa inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678917-B2 | Factor Xa inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7601752-B2 | Pyrrolidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-10-13 | — | — | US | disclosed |
| CN-101309919-A | Novel pyrrolidine derivatives as inhibitors of coagulation factor XA | HOFFMANN LA ROCHE (CH) | 2008-11-19 | — | — | CN | disclosed |
| CN-101300252-A | Novel cycloalkane carboxamides as factor Xa inhibitors | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | CN | disclosed |
| EP-1951717-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR XA | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-06 | — | — | EP | disclosed |
| EP-1928864-A1 | NOVEL CYCLOALKANE CARBOXAMIDES AS FACTOR XA INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007057317-A1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR XA | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-24 | — | — | WO | disclosed |
| US-20070112001-A1 | Pyrrolidine derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-05-17 | — | — | US | disclosed |
| WO-2007025949-A1 | NOVEL CYCLOALKANE CARBOXAMIDES AS FACTOR XA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007025949-A1 | NOVEL CYCLOALKANE CARBOXAMIDES AS FACTOR XA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049587-A1 | Factor Xa inhibitors | HOFFMANN-LA ROCHE INC. | 2007-03-01 | — | — | US | disclosed |
| US-20070049587-A1 | Factor Xa inhibitors | HOFFMANN-LA ROCHE INC. | 2007-03-01 | — | — | US | disclosed |
| US-20070049587-A1 | Factor Xa inhibitors | HOFFMANN-LA ROCHE INC. | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049587-A1 | Factor Xa inhibitors | F12, F11, F10 | PIK3CD 3657/4885F10 3/4885PTGS2 1679/4885 |
| US-20070112001-A1 | Pyrrolidine derivatives | F12, F2, F11 | PIK3CD 3583/4885F10 7/4885PTGS2 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.