Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.74 |
| ▸ | LMNA | P02545 | 9/20 | 0.74 |
| ▸ | MAPT | P10636 | 10/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240376 | 0.93 | ALDH1A1 (0.65) | ALDH1A1LMNAMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL27927947 | 0.90 | ALDH1A1 (0.76) | ALDH1A1LMNAMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL2530427 | 0.87 | ALDH1A1 (0.72) | ALDH1A1LMNAMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL2530426 | 0.87 | ALDH1A1 (0.72) | ALDH1A1LMNAMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL3542256 | 0.86 | LMNA (0.70) | ALDH1A1LMNAMAPTSMN1; SMN2GAA | |
| SCHEMBL899915 | 0.86 | ALDH1A1 (0.74) | ALDH1A1LMNAMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL2530564 | 0.85 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL3553731 | 0.85 | LMNA (0.69) | ALDH1A1LMNAMAPTGAAMEN1 | |
| SCHEMBL30957484 | 0.85 | LMNA (0.69) | ALDH1A1LMNAMAPTGAAMEN1 | |
| SCHEMBL13114779 | 0.83 | ALDH1A1 (0.71) | ALDH1A1LMNAMAPTSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61027975-A | — | — | None | — | — | JP | disclosed |
| US-7655652-B2 | 2-{4-[4-(2-hydroxyacetyl)piperazin-1-yl]anilino}-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-5-fluoropyrimidine hydrochloride; cell cycle inhibitory; rheumatoid arthritis | ASTRAZENECA AB (SE) | 2010-02-02 | — | — | US | disclosed |
| CN-100528865-C | Imidazolo-5-yl-anilinopyrimidines as agents for the inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2009-08-19 | — | — | CN | disclosed |
| US-20070161615-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
| CN-1938295-A | Imidazol-5-yl-anilinopyrimidines as cell proliferation inhibitors | ASTRAZENECA AB (SE) | 2007-03-28 | — | — | CN | disclosed |
| JP-S6127975-A | PIPERZINE COMPOUND AND PREPARATION THEREOF | NIPPON KAYAKU CO LTD | 1986-02-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161615-A1 | Chemical compounds | MKI67, PCNA, CCNI | ALDH1A1 320/4885LMNA 988/4885MAPT 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.