Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.65 |
| ▸ | LMNA | P02545 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 10/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547962 | 0.93 | ALDH1A1 (0.74) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL3553731 | 0.86 | LMNA (0.69) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL30957484 | 0.86 | LMNA (0.69) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL27927947 | 0.83 | ALDH1A1 (0.76) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL2530427 | 0.81 | ALDH1A1 (0.72) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL2530426 | 0.81 | ALDH1A1 (0.72) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL3542256 | 0.80 | LMNA (0.70) | ALDH1A1LMNAMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL899915 | 0.80 | ALDH1A1 (0.74) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL2530564 | 0.79 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL13114779 | 0.77 | ALDH1A1 (0.71) | ALDH1A1LMNAMAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |