Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401694 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4ETSHRSMN1; SMN2NPSR1 | |
| Aniline SCHEMBL3548033 | 0.78 | NPC1 (0.54) | NPC1RAB9ALTA4HALDH1A1KDM4E | |
| SCHEMBL1911850 | 0.78 | NPC1 (0.66) | NPC1RAB9AMAPK1ALDH1A1KDM4E | |
| SCHEMBL29788588 | 0.77 | ALDH1A1 (0.58) | NPC1RAB9ALTA4HMAPK1ALDH1A1 | |
| SCHEMBL375708 | 0.77 | ALDH1A1 (0.58) | NPC1RAB9ALTA4HMAPK1ALDH1A1 | |
| SCHEMBL12311750 | 0.75 | NPC1 (0.70) | NPC1RAB9AMAPK1ALDH1A1KDM4E | |
| SCHEMBL11876984 | 0.75 | NPC1 (0.70) | NPC1RAB9ALTA4HALDH1A1KDM4E | |
| SCHEMBL12312257 | 0.74 | ALDH1A1 (0.58) | NPC1RAB9ALTA4HMAPK1ALDH1A1 | |
| SCHEMBL13791083 | 0.74 | SYK (0.59) | NPC1MAPK1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL15474582 | 0.74 | ALDH1A1 (0.54) | NPC1RAB9ALTA4HALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | NPC1 13/4885RAB9A 1172/4885LTA4H 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.