Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5107365 | 0.83 | ALDH1A1 (0.69) | HPGDGAAALDH1A1MAPTRAB9A | |
| SCHEMBL6113460 | 0.82 | HPGD (0.62) | HPGDGAAALDH1A1MAPTRAB9A | |
| SCHEMBL15697516 | 0.81 | ATM (0.52) | HPGDALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL387186 | 0.80 | ERN1 (0.61) | ALDH1A1MAPTLMNANFE2L2KDM4E | |
| SCHEMBL459873 | 0.78 | ERN1 (0.62) | HPGDGAAALDH1A1MAPTMEN1 | |
| SCHEMBL8943686 | 0.77 | MAPT (0.64) | HPGDGAAALDH1A1MAPTRAB9A | |
| SCHEMBL6441737 | 0.76 | ALDH1A1 (0.73) | HPGDGAAALDH1A1MAPTRAB9A | |
| SCHEMBL9418310 | 0.76 | RXFP1 (0.79) | HPGDGAAALDH1A1MAPTRAB9A | |
| SCHEMBL51509 | 0.76 | RXFP1 (0.79) | HPGDGAAALDH1A1MAPTRAB9A | |
| SCHEMBL25688773 | 0.76 | CYP1A2 (0.53) | HPGDGAAALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807692-B2 | Antidiabetic oxazolidinediones and thiazolidinediones | MERCK SHARP & DOHME CORP. (US) | 2010-10-05 | — | — | US | disclosed |