Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.60 |
| ▸ | CDK4 | P11802 | 1/20 | 0.60 |
| ▸ | CCND1 | P24385 | 1/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 6/20 | 0.60 |
| ▸ | GSK3B | P49841 | 6/20 | 0.60 |
| ▸ | PRKCB | P05771 | 5/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.60 |
| ▸ | PRKCG | P05129 | 3/20 | 0.60 |
| ▸ | PRKCH | P24723 | 2/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.59 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.57 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.57 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.57 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.57 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547465 | 0.85 | CDK4 (0.60) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL4370794 | 0.85 | GSK3B (0.51) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL3553175 | 0.81 | PRKCH (0.64) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7987757 | 0.81 | CCNE2 (0.66) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL30319849 | 0.78 | CCNE2 (1.00) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL5686048 | 0.78 | CCNE2 (1.00) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL4543351 | 0.76 | PRKCB (0.69) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL4346607 | 0.76 | GSK3B (1.00) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL4343058 | 0.76 | GSK3B (1.00) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL990030 | 0.76 | GSK3B (0.62) | CCNE2CDK4CCND1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747216-B1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2014-01-08 | — | — | EP | claimed |
| US-7851475-B2 | Substituted pyrrole-2, 5-diones as protein kinase C inhibitors | NOVARTIS AG (CH) | 2010-12-14 | — | — | US | claimed |
| US-20090221605-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2009-09-03 | — | — | US | claimed |
| EP-1747216-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | Novartis Pharma AG. (CH) | 2007-01-31 | — | — | EP | claimed |
| WO-2005113545-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | NOVARTIS AG (CH) | 2005-12-01 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221605-A1 | SUBSTITUTED PYRROLE-2, 5-DIONES AS PROTEIN KINASE C INHIBITORS | PRKCA, PRKCB, PRKCE | CCNE2 602/4885CDK4 193/4885CCND1 582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.