Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 6/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3550073 | 0.99 | MTNR1B (0.39) | MTNR1BMTNR1ADRD4CHRNA7HTR3A | |
| SCHEMBL3542038 | 0.94 | MTNR1B (0.46) | MTNR1BMTNR1AGPR84ALOX5HTR2A | |
| Hydrochloric Acid SCHEMBL3546035 | 0.94 | MTNR1B (0.45) | MTNR1BMTNR1AGPR84ALOX5HTR2A | |
| SCHEMBL5011585 | 0.85 | GPR84 (0.39) | MTNR1BMTNR1ADRD4GPR84HTR2A | |
| SCHEMBL3547527 | 0.85 | HTR1B (0.44) | MTNR1BMTNR1ADRD4GPR84ALOX5 | |
| Hydrochloric Acid SCHEMBL5013248 | 0.84 | GPR84 (0.38) | MTNR1BDRD4GPR84HTR2AMEN1 | |
| Hydrochloric Acid SCHEMBL3548068 | 0.84 | HTR1B (0.43) | MTNR1BMTNR1ADRD4GPR84MEN1 | |
| SCHEMBL3551354 | 0.83 | MTNR1B (0.42) | MTNR1BMTNR1AGPR84ALOX5HTR2A | |
| Hydrochloric Acid SCHEMBL3541534 | 0.82 | MTNR1B (0.41) | MTNR1BMTNR1AGPR84ALOX5HTR2A | |
| SCHEMBL3549158 | 0.81 | NOS3 (0.35) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741343-B2 | 6H-oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2010-06-22 | — | — | US | disclosed |
| US-20080051394-A1 | 6H-Oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | SCHIEMANN KAI | 2008-02-28 | — | — | US | disclosed |
| US-7291633-B2 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2007-11-06 | — | — | US | disclosed |
| US-20050101649-A1 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2005-05-12 | — | — | US | disclosed |
| EP-1392699-B1 | 6H-OXAZOLO 4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2005-03-16 | — | — | EP | disclosed |
| EP-1392699-A1 | 6H-OXAZOLO 4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GmbH (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002088139-A1 | 6H-OXAZOLO[4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051394-A1 | 6H-Oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | CHRM1, CHRNA5, CHRNA4 | MTNR1B 214/4885MTNR1A 171/4885DRD4 103/4885 |
| US-20050101649-A1 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | CHRM1, CHRNA5, CHRNA4 | MTNR1B 213/4885MTNR1A 171/4885DRD4 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.