Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751776 | 0.82 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL1751778 | 0.82 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL1752015 | 0.80 | GABRB3 (0.40) | ALDH1A1HPGDTDP1 | |
| SCHEMBL1752016 | 0.80 | GABRB3 (0.40) | ALDH1A1HPGDTDP1 | |
| SCHEMBL4962616 | 0.73 | ALDH1A1 (0.32) | ALDH1A1HPGDTDP1 | |
| SCHEMBL4963345 | 0.70 | GABRP (0.42) | ALDH1A1HPGDTDP1 | |
| SCHEMBL1752246 | 0.67 | GABRB3 (0.39) | ALDH1A1HPGD | |
| SCHEMBL1752247 | 0.67 | GABRB3 (0.39) | ALDH1A1HPGD | |
| SCHEMBL2000168 | 0.67 | GABRB3 (0.43) | ALDH1A1HPGDTDP1 | |
| SCHEMBL2001894 | 0.64 | GABRB3 (0.42) | ALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645786-B2 | 1-aryl-4-cyclopropylpyrazoles with at least one fluorine attached to the cyclopropyl ring; parasiticides; fleas; extended duration of action for at least 28 days | PFIZER INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20070149550-A1 | 1-aryl-4-cyclopropylpyrazoles with at least one fluorine attached to the cyclopropyl ring; parasiticides; fleas; extended duration of action for at least 28 days | PFIZER INC. (US) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149550-A1 | 1-aryl-4-cyclopropylpyrazoles with at least one fluorine attached to the cyclopropyl ring; parasiticides; fleas; extended duration of action for at least 28 days | CYP3A43, CYP3A4, CYP2F1 | ALDH1A1 559/4885HPGD 3207/4885TDP1 2780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.