Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KIF20A | O95235 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554596 | 0.85 | NPC1 (0.46) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3554594 | 0.85 | NPC1 (0.46) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3552968 | 0.81 | ALDH1A1 (0.43) | KAT6AMAPTLMNARAB9ANPC1 | |
| SCHEMBL3552970 | 0.81 | ALDH1A1 (0.43) | KAT6AMAPTLMNARAB9ANPC1 | |
| SCHEMBL3562068 | 0.79 | ALDH1A1 (0.37) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3562070 | 0.79 | ALDH1A1 (0.37) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3562064 | 0.76 | NPC1 (0.46) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3562061 | 0.76 | NPC1 (0.46) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14379044 | 0.73 | ORAI1 (0.42) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3559709 | 0.73 | ORAI1 (0.42) | MAPTLMNARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705029-B2 | Acrylonitrile derivatives for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20070270478-A1 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270478-A1 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | IL1B, IL6, TLR4 | KAT6A 1540/4885MAPT 643/4885LMNA 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.