Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548045 | 0.90 | ADORA3 (0.56) | ADORA2AADORA3ADORA2BADORA1MAPK8 | |
| SCHEMBL3545741 | 0.83 | RXFP1 (0.55) | ADORA2AADORA3ADORA1MAPK1SQOR | |
| SCHEMBL11924394 | 0.83 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1ROCK2 | |
| SCHEMBL26010519 | 0.80 | ADORA1 (0.52) | ADORA2AADORA1ROCK2CSF1RMAPK1 | |
| SCHEMBL7017972 | 0.76 | ALDH1A1 (0.49) | ADORA2AADORA3ADORA1ROCK2CSF1R | |
| SCHEMBL11924430 | 0.75 | PDE4A (0.52) | ADORA2AADORA3ADORA2BROCK2CSF1R | |
| SCHEMBL11924429 | 0.74 | PDE4A (0.51) | ADORA2AADORA3ADORA2BMAPK10ALDH1A1 | |
| SCHEMBL7018457 | 0.74 | ALDH1A1 (0.64) | ADORA2AADORA3ADORA1ROCK2CSF1R | |
| SCHEMBL7013023 | 0.73 | ADORA3 (0.65) | ADORA2AADORA3ADORA2BADORA1MAPK1 | |
| SCHEMBL4306407 | 0.72 | ADORA3 (0.64) | ADORA2AADORA3ADORA2BADORA1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855219-B2 | Substituted 2-oxy-3,5-dicyano-4aryl-6-aminopyridines and use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-12-21 | — | — | US | disclosed |
| US-7855219-B2 | Substituted 2-oxy-3,5-dicyano-4aryl-6-aminopyridines and use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-12-21 | — | — | US | disclosed |
| US-7855219-B2 | Substituted 2-oxy-3,5-dicyano-4aryl-6-aminopyridines and use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-12-21 | — | — | US | disclosed |
| US-20050261502-A1 | Substituted 2-oxy-3,5-dicyano-4-aryl-6-aminopyridines and use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261502-A1 | Substituted 2-oxy-3,5-dicyano-4-aryl-6-aminopyridines and use thereof | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA3 2/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.