Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24883512 | 0.84 | HDAC1 (0.61) | HDAC1HDAC2HDAC3MCL1HTR1A | |
| SCHEMBL30174165 | 0.83 | HDAC1 (0.66) | HDAC1HDAC2HDAC3MEN1KMT2A | |
| SCHEMBL3551679 | 0.83 | HDAC1 (0.66) | HDAC1HDAC2HDAC3MEN1KMT2A | |
| SCHEMBL30174163 | 0.83 | HDAC1 (0.66) | HDAC1HDAC2HDAC3MEN1KMT2A | |
| SCHEMBL19308452 | 0.83 | HDAC1 (0.65) | HDAC1HDAC2HDAC3MEN1KMT2A | |
| SCHEMBL24883506 | 0.81 | HDAC1 (0.60) | HDAC1HDAC2HDAC3MEN1KMT2A | |
| SCHEMBL17373163 | 0.81 | HDAC1 (0.62) | HDAC1HDAC2HDAC3MEN1KMT2A | |
| SCHEMBL13753351 | 0.80 | MCL1 (0.61) | HDAC1HDAC2HDAC3MEN1KMT2A | |
| SCHEMBL16596183 | 0.79 | HDAC1 (0.74) | HDAC1HDAC2HDAC3MEN1KMT2A | |
| SCHEMBL24883665 | 0.78 | HDAC1 (0.70) | HDAC1HDAC2HDAC3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116869-A1 | INDOLE CARBOXAMIDE COMPOUND, PREPARATION THEREFOR AND USE THEREOF | NANJING RUISHUNING MEDICAL TECHNOLOGY CO., LTD. (CN) | 2024-04-11 | — | — | US | disclosed |
| WO-2023280061-A1 | INDOLE FORMAMIDE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 西北农林科技大学 | 2023-01-12 | — | — | WO | disclosed |
| US-7732436-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-06-08 | — | — | US | disclosed |
| US-7601710-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2009-10-13 | — | — | US | disclosed |
| US-7601710-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2009-10-13 | — | — | US | disclosed |
| US-7385055-B2 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2008-06-10 | — | — | US | disclosed |
| US-7335769-B2 | Preparation of hymenialdsine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2008-02-26 | — | — | US | disclosed |
| US-7193079-B1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-03-20 | — | — | US | disclosed |
| US-20070049575-A1 | PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2007-03-01 | — | — | US | disclosed |
| US-20070049575-A1 | PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2007-03-01 | — | — | US | disclosed |
| US-20060293305-A1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2006-12-28 | — | — | US | disclosed |
| US-20060287296-A1 | Preparation of hymenialdsine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2006-12-21 | — | — | US | disclosed |
| US-20060276451-A1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2006-12-07 | — | — | US | disclosed |
| WO-2004103958-A2 | PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF | MICHIGAN STATE UNIVERSITY (US) | 2004-12-02 | — | — | WO | disclosed |
| US-20040235820-A1 | Preparation of hymenialdisine derivatives and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287296-A1 | Preparation of hymenialdsine derivatives and use thereof | IDO2, CHEK2, NFKBIA | HDAC1 890/4885HDAC2 109/4885HDAC3 866/4885 |
| US-20040235820-A1 | Preparation of hymenialdisine derivatives and use thereof | NFKBIA, IKBKG, GSK3B | HDAC1 939/4885HDAC2 126/4885HDAC3 627/4885 |
| US-20240116869-A1 | INDOLE CARBOXAMIDE COMPOUND, PREPARATION THEREFOR AND USE THEREOF | IDO1, IDO2, LITAF | HDAC1 710/4885HDAC2 432/4885HDAC3 2506/4885 |
| US-20070049575-A1 | PREPARATION OF HYMENIALDISINE DERIVATIVES AND USE THEREOF | IDO2, CHEK2, NFKBIA | HDAC1 861/4885HDAC2 115/4885HDAC3 875/4885 |
| US-20060276451-A1 | Preparation of hymenialdisine derivatives and use thereof | IDO2, CHEK2, NFKBIA | HDAC1 861/4885HDAC2 115/4885HDAC3 875/4885 |
| US-20060293305-A1 | Preparation of hymenialdisine derivatives and use thereof | IDO2, CHEK2, NFKBIA | HDAC1 861/4885HDAC2 115/4885HDAC3 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.