Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556756 | 1.00 | MAPK1 (0.40) | MAPK1CA12CA9KMT2ASMN1; SMN2 | |
| SCHEMBL3559325 | 0.86 | MAPK1 (0.40) | MAPK1CA12CA9KMT2ASMN1; SMN2 | |
| SCHEMBL13349422 | 0.84 | PDK4 (0.41) | HSD17B10 | |
| SCHEMBL27679483 | 0.80 | CA12 (0.45) | CA12CA9KMT2ASMN1; SMN2GAA | |
| SCHEMBL13315681 | 0.80 | HSD17B10 (0.35) | CA12CA9KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL3139356 | 0.76 | HSD17B10 (0.46) | MAPK1CA12CA9KMT2ASMN1; SMN2 | |
| SCHEMBL3559446 | 0.74 | CASP3 (0.38) | MAPK1CA12CA9ALDH1A1 | |
| SCHEMBL3559442 | 0.74 | CASP3 (0.38) | MAPK1CA12CA9ALDH1A1 | |
| SCHEMBL3559448 | 0.74 | CASP3 (0.38) | MAPK1CA12CA9ALDH1A1 | |
| SCHEMBL3124256 | 0.73 | ALDH1A1 (0.45) | MAPK1CA12CA9KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732612-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-06-08 | — | — | US | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| EP-1675852-B1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | EP | disclosed |
| US-7179805-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-20 | — | — | US | disclosed |
| US-20060052359-A1 | 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-03-09 | — | — | US | disclosed |
| US-20050101588-A1 | 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones | GRANT EUGENE B III (US) | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052359-A1 | 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones | NQO2, NQO1, REN | MAPK1 2562/4885CA12 3691/4885CA9 2020/4885 |
| US-20050101588-A1 | 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones | NQO2, NQO1, REN | MAPK1 2562/4885CA12 3691/4885CA9 2020/4885 |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | NQO2, QRFPR, NQO1 | MAPK1 2916/4885CA12 3602/4885CA9 1820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.