⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924663 | 1.00 | — | — | |
| Ethylene SCHEMBL8926624 | 0.97 | — | — | |
| SCHEMBL14155712 | 0.86 | SIGMAR1 (0.42) | — | |
| SCHEMBL4983527 | 0.84 | EP300 (0.42) | — | |
| SCHEMBL28965319 | 0.82 | PARP1 (0.38) | — | |
| SCHEMBL22873345 | 0.79 | MAPT (0.45) | — | |
| SCHEMBL28041842 | 0.79 | RGS4 (0.41) | — | |
| SCHEMBL755504 | 0.79 | MAPT (0.45) | — | |
| SCHEMBL5850350 | 0.79 | ABCB1 (0.41) | — | |
| SCHEMBL28041981 | 0.79 | HPGD (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401838-B1 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-26 | — | — | EP | disclosed |
| US-7732437-B2 | Use of anti-histaminics for acute reduction of elevated intracranial pressure | JANSSEN PHARMACEUTICA, NV. (BE) | 2010-06-08 | — | — | US | disclosed |
| US-7476662-B2 | Substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-13 | — | — | US | disclosed |
| EP-1451196-B1 | The use of substituted tetracyclic imidazole derivatives as anti-histaminics | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050070525-A1 | Use of anti-histaminics for acute reduction of elevated intracranial pressure | JANSSEN-CILAG GMBH (DE) | 2005-03-31 | — | — | US | disclosed |
| EP-1451196-A1 | THE USE OF ANTI-HISTAMINICS FOR ACUTE REDUCTION OF ELEVATED INTRACRANIAL PRESSURE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-09-01 | — | — | EP | disclosed |
| US-20040167138-A1 | Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharamaceutical compositions comprising them and their use as a medicine | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-08-26 | — | — | US | disclosed |
| EP-1401838-A2 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-31 | — | — | EP | disclosed |
| CN-1111529-C | Piperazino-derivatives as neurokinin | SCHERING CORP (US) | 2003-06-18 | — | — | CN | disclosed |
| WO-2003044023-A1 | THE USE OF ANTI-HISTAMINICS FOR ACUTE REDUCTION OF ELEVATED INTRACRANIAL PRESSURE | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-05-30 | — | — | WO | disclosed |
| WO-2002100862-A2 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-12-19 | — | — | WO | disclosed |
| CN-1200120-A | Piperazino derivatives as neurokinin antagonists | SCHERING CORP (US) | 1998-11-25 | — | — | CN | disclosed |