Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346733 | 0.83 | TRPM5 (0.43) | NOS1DYRK1APIK3CGCYP2A6PSMB8 | |
| SCHEMBL16595870 | 0.76 | NOS1 (0.45) | NOS1DYRK1ACYP2A6CYP1A2MAPT | |
| SCHEMBL2007740 | 0.74 | PPARD (0.33) | — | |
| SCHEMBL29442070 | 0.74 | KDM4E (0.44) | PSMB8LMNAMAPTALOX15 | |
| SCHEMBL29941780 | 0.74 | CA12 (0.44) | LMNACYP1A2MAPTALOX15CA12 | |
| SCHEMBL1837755 | 0.74 | CA12 (0.44) | LMNACYP1A2MAPTALOX15CA12 | |
| SCHEMBL9342433 | 0.73 | AHR (0.37) | AHRTRPM5 | |
| SCHEMBL9346645 | 0.72 | TDO2 (0.44) | DYRK1ATDO2LMNACYP1A2AHR | |
| SCHEMBL24463586 | 0.69 | CYP1A1 (0.34) | — | |
| SCHEMBL21267380 | 0.69 | AKR1C3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111777478-B | Synthetic method of para-acylaniline sulfonamide compound | 五邑大学 | 2022-10-28 | — | — | CN | disclosed |
| CN-112552235-B | Synthetic method of 2, 3-diacyl quinoline compound | 江南大学 | 2021-12-28 | — | — | CN | disclosed |
| CN-110483511-B | Synthetic method of quinazolinone polycyclic compound | 常州大学 | 2021-06-22 | — | — | CN | disclosed |
| CN-112552235-A | Synthetic method of 2, 3-diacyl quinoline compound | 江南大学 | 2021-03-26 | — | — | CN | disclosed |
| CN-111777478-A | Synthetic method of para-acylaniline sulfonamide compound | 五邑大学 | 2020-10-16 | — | — | CN | disclosed |
| CN-110483511-A | A kind of synthetic method of quinazolinone polycyclic compounds | UNIV CHANGZHOU | 2019-11-22 | — | — | CN | disclosed |
| US-7696238-B2 | Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics | GRUENENTHAL GMBH (DE) | 2010-04-13 | — | — | US | disclosed |
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | GRUENENTHAL GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
| EP-0573467-B1 | NEUROLEPTIC PERHYDRO-1H-PYRIDO 1,2-a]PYRAZINES | PFIZER (US) | 1995-05-31 | — | — | EP | disclosed |
| EP-0420464-B1 | 3-Isoxazolone derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| US-5321037-A | Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants | SANKYO COMPANY, LIMITED (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0573467-A1 | NEUROLEPTIC PERHYDRO-1H-PYRIDO 1,2-a]PYRAZINES. | PFIZER (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5157034-A | Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines | PFIZER INC. (US) | 1992-10-20 | — | — | US | disclosed |
| WO-1992015580-A1 | NEUROLEPTIC PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES | PFIZER INC. (US) | 1992-09-17 | — | — | WO | disclosed |
| EP-0335723-B1 | ISOXAZOLE DERIVATIVES FOR USE AS CEREBRO-ACTIVE DRUGS AND CENTRAL MUSCLE RELAXANTS | Sankyo Company Limited (JP) | 1991-12-04 | — | — | EP | disclosed |
| EP-0420464-A2 | 3-Isoxazolone derivatives, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1991-04-03 | — | — | EP | disclosed |
| EP-0335723-A1 | Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants | Sankyo Company Limited (JP) | 1989-10-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | KCNQ1, KCNQ2, KCNQ3 | NOS1 3376/4885DYRK1A 2836/4885PIK3CG 3749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.