Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3139314 | 0.84 | — | — | |
| SCHEMBL3133998 | 0.83 | — | — | |
| SCHEMBL3133997 | 0.83 | — | — | |
| SCHEMBL3132103 | 0.82 | OPRD1 (0.31) | OPRM1OPRD1OPRK1 | |
| SCHEMBL29925113 | 0.79 | OPRD1 (0.33) | OPRM1OPRD1OPRK1DPP7 | |
| Hydrochloric Acid SCHEMBL26127886 | 0.78 | OPRD1 (0.32) | OPRM1OPRD1OPRK1DPP7 | |
| SCHEMBL3135565 | 0.75 | ALDH1A1 (0.42) | OPRM1OPRD1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3558736 | 0.72 | OPRD1 (0.32) | OPRM1OPRD1OPRK1DPP7 | |
| SCHEMBL3137451 | 0.70 | — | — | |
| SCHEMBL3137108 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861401-B1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-18 | — | — | EP | disclosed |
| US-7732612-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-06-08 | — | — | US | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| EP-1675852-B1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | EP | disclosed |
| EP-1861401-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-05 | — | — | EP | disclosed |
| US-7179805-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-20 | — | — | US | disclosed |
| WO-2006101603-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-28 | — | — | WO | disclosed |
| EP-1675852-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | Janssen Pharmaceutica N.V. (BE) | 2006-07-05 | — | — | EP | disclosed |
| US-20060052359-A1 | 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-03-09 | — | — | US | disclosed |
| US-20050101588-A1 | 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones | GRANT EUGENE B III (US) | 2005-05-12 | — | — | US | disclosed |
| WO-2005033108-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052359-A1 | 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones | NQO2, NQO1, REN | OPRM1 351/4885OPRD1 618/4885OPRK1 518/4885 |
| US-20050101588-A1 | 7-Amino alkylidenyl-heterocyclic quinolones and naphthyridones | NQO2, NQO1, REN | OPRM1 351/4885OPRD1 618/4885OPRK1 518/4885 |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | NQO2, QRFPR, NQO1 | OPRM1 439/4885OPRD1 722/4885OPRK1 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.