Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4343506 | 0.99 | HTR1A (0.69) | HTR1A | |
| Hydrochloric Acid SCHEMBL4559862 | 0.98 | HTR1A (0.68) | HTR1A | |
| Hydrochloric Acid SCHEMBL4337711 | 0.98 | HTR1A (0.68) | HTR1A | |
| SCHEMBL4350020 | 0.88 | HTR1A (0.68) | HTR1A | |
| SCHEMBL4347680 | 0.84 | HTR1A (0.52) | HTR1A | |
| SCHEMBL3557770 | 0.83 | HTR1A (1.00) | HTR1A | |
| SCHEMBL3559471 | 0.80 | HTR1A (1.00) | HTR1A | |
| SCHEMBL3562420 | 0.79 | HTR1A (1.00) | HTR1A | |
| SCHEMBL3560400 | 0.79 | HTR1A (0.81) | HTR1A | |
| SCHEMBL28770623 | 0.78 | HTR1A (0.85) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029577-A2 | CRYSTALLINE FORMS OF 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE | Wyeth (US) | 2009-03-04 | — | — | EP | claimed |
| EP-2027112-A2 | SUCCINATE SALTS OF 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE AND CRYSTALLINE FORMS THEREOF | Wyeth (US) | 2009-02-25 | — | — | EP | claimed |
| EP-2027111-A2 | 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE HYDROCHLORIC ACID SALTS | Wyeth (US) | 2009-02-25 | — | — | EP | claimed |
| US-20080119481-A1 | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline | WYETH (US) | 2008-05-22 | — | — | US | claimed |
| US-20080045510-A1 | Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof | WYETH (US) | 2008-02-21 | — | — | US | claimed |
| US-20070299083-A1 | 6-Methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts | WYETH (US) | 2007-12-27 | — | — | US | claimed |
| WO-2007146116-A2 | CRYSTALLINE FORMS OF 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE | WYETH (US) | 2007-12-21 | — | — | WO | claimed |
| WO-2007146115-A2 | 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE HYDROCHLORIC ACID SALTS | WYETH (US) | 2007-12-21 | — | — | WO | claimed |
| WO-2007146202-A2 | SUCCINATE SALTS OF 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE AND CRYSTALLINE FORMS THEREOF | WYETH (US) | 2007-12-21 | — | — | WO | claimed |
| US-7671056-B2 | Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor | WYETH LLC (US) | 2010-03-02 | — | — | US | disclosed |
| CN-101466701-A | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline | WYETH CORP (US) | 2009-06-24 | — | — | CN | disclosed |
| CN-101466701-A | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline | WYETH CORP (US) | 2009-06-24 | — | — | CN | disclosed |
| CN-101460486-A | Succinate salts of 6-methoxy-8- [ 4- (1- (5-fluoro) -quinolin-8-yl-piperidin-4-yl) -piperazin-1-yl ] -quinoline and crystalline forms thereof | WYETH CORP (US) | 2009-06-17 | — | — | CN | disclosed |
| CN-101460486-A | Succinate salts of 6-methoxy-8- [ 4- (1- (5-fluoro) -quinolin-8-yl-piperidin-4-yl) -piperazin-1-yl ] -quinoline and crystalline forms thereof | WYETH CORP (US) | 2009-06-17 | — | — | CN | disclosed |
| WO-2007146116-A2 | CRYSTALLINE FORMS OF 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146116-A2 | CRYSTALLINE FORMS OF 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146115-A2 | 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE HYDROCHLORIC ACID SALTS | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146116-A2 | CRYSTALLINE FORMS OF 6-METHOXY-8-[4-(1-(5-FLUORO)-QUINOLIN-8-YL-PIPERIDIN-4-YL)-PIPERAZIN-1-YL]-QUINOLINE | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |
| US-20070027160-A1 | 5-fluoro-8-(4-(4-(6-methoxyquinolin-8-yl)piperazin-1-yl)piperidin-1-yl)quinoline; central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
| WO-2006135839-A2 | PIPERAZINE-PIPERIDINE ANTAGONISTS AND AGONISTS OF THE 5-HT1A RECEPTOR | WYETH (US) | 2006-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299083-A1 | 6-Methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts | HTR5A, HTR2C, HTR1A | HTR1A 3/4885 |
| US-20070027160-A1 | 5-fluoro-8-(4-(4-(6-methoxyquinolin-8-yl)piperazin-1-yl)piperidin-1-yl)quinoline; central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction | HTR5A, HTR2C, HTR1D | HTR1A 4/4885 |
| US-20080045510-A1 | Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof | HTR5A, SUCNR1, HTR2C | HTR1A 4/4885 |
| US-20080119481-A1 | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline | HTR5A, HTR2C, HTR1A | HTR1A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.