Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | WDR5 | P61964 | 2/20 | 0.53 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3559521 | 0.97 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAKEAP1NFE2L2CA12 | |
| SCHEMBL3561138 | 0.96 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAKEAP1NFE2L2CA12 | |
| SCHEMBL3552935 | 0.87 | SLC16A3 (0.68) | SMN1; SMN2LMNAKEAP1NFE2L2CA12 | |
| SCHEMBL3557420 | 0.87 | SLC16A3 (0.62) | SMN1; SMN2LMNAKEAP1NFE2L2CA12 | |
| SCHEMBL3551774 | 0.86 | LMNA (0.58) | SMN1; SMN2LMNAKEAP1NFE2L2MEN1 | |
| SCHEMBL28784798 | 0.85 | LMNA (0.68) | SMN1; SMN2LMNAKEAP1NFE2L2CA12 | |
| SCHEMBL3560551 | 0.85 | KEAP1 (0.54) | KEAP1NFE2L2MEN1KMT2ASLC16A3 | |
| SCHEMBL3563389 | 0.84 | MEN1 (0.76) | SMN1; SMN2LMNAMEN1KMT2ASLC16A3 | |
| SCHEMBL3554581 | 0.83 | KDM4E (0.54) | MEN1KMT2ASLC16A3KDM4EALDH1A1 | |
| SCHEMBL3563777 | 0.83 | LMNA (0.57) | SMN1; SMN2LMNAKEAP1NFE2L2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816397-B2 | Phenylcarboxylic acid derivatives and use thereof for the treatment of diabetes | MERCK PATENT GMBH (DE) | 2010-10-19 | — | — | US | claimed |
| US-20080045483-A1 | Phenylcarboxylic Acid Derivatives and Use Thereof for the Treatment of Diabetes | MERCK PATENT GMBH (DE) | 2008-02-21 | — | — | US | claimed |
| US-7816397-B2 | Phenylcarboxylic acid derivatives and use thereof for the treatment of diabetes | MERCK PATENT GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-20080045483-A1 | Phenylcarboxylic Acid Derivatives and Use Thereof for the Treatment of Diabetes | MERCK PATENT GMBH (DE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045483-A1 | Phenylcarboxylic Acid Derivatives and Use Thereof for the Treatment of Diabetes | SLC5A1, ALDH7A1, ASS1 | SMN1; SMN2 4522/4885LMNA 2120/4885KEAP1 1284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.