Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.37 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556322 | 0.91 | ORAI1 (0.41) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL13438433 | 0.91 | ORAI1 (0.41) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL5184445 | 0.90 | TRPC3 (0.39) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL3565073 | 0.87 | TRPV1 (0.38) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL3561052 | 0.85 | ORAI1 (0.37) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL5184449 | 0.83 | CRACR2A (0.40) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL3559491 | 0.82 | ALDH1A1 (0.46) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL3559475 | 0.82 | CRACR2A (0.37) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL3557306 | 0.82 | ORAI1 (0.42) | ALDH1A1ORAI1TRPC1TRPC3STIM1 | |
| SCHEMBL3559317 | 0.80 | ALDH1A1 (0.39) | ALDH1A1TP53MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705029-B2 | Acrylonitrile derivatives for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20070270478-A1 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270478-A1 | ACRYLONITRILE DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES | IL1B, IL6, TLR4 | ALDH1A1 472/4885ORAI1 3017/4885TRPC1 3621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.