Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10031417 | 0.86 | INSR (0.38) | INSRKDM4AKDM2AAPPCNR2 | |
| Iodide SCHEMBL352068 | 0.80 | KDM4E (0.37) | INSRKDM4AKDM2AAPPCNR2 | |
| SCHEMBL356229 | 0.75 | PRKCI (0.40) | INSRAPPNPC1RAB9AKDM4E | |
| SCHEMBL353810 | 0.75 | PRKCI (0.40) | INSRAPPNPC1RAB9AKDM4E | |
| SCHEMBL354255 | 0.75 | INSR (0.34) | INSRAPPCNR2NPC1RAB9A | |
| SCHEMBL354483 | 0.75 | KDM4E (0.47) | INSRNPC1RAB9AKDM4ELMNA | |
| Iodide SCHEMBL352942 | 0.74 | HTT (0.38) | INSRKDM4AKDM2AAPPNPC1 | |
| SCHEMBL354452 | 0.74 | INSR (0.35) | INSRAPPCNR2PTGESALOX5 | |
| SCHEMBL354256 | 0.73 | INSR (0.33) | INSRAPPCNR2NPC1RAB9A | |
| SCHEMBL16503876 | 0.73 | INSR (0.38) | INSRKDM4AKDM2AAPPNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015399-A1 | FLUORESCENT SOLVATOCHROMIC PIGMENT | NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) | 2012-01-19 | — | — | US | disclosed |
| EP-2395055-A1 | FLUORESCENT SOLVATOCHROMIC PIGMENT | National University Corporation Hokkaido University (JP) | 2011-12-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015399-A1 | FLUORESCENT SOLVATOCHROMIC PIGMENT | ANXA5, TRPV5, TRPC5 | INSR 4089/4885KDM4A 4075/4885KDM2A 4416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.