Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.50 |
| ▸ | MDH1 | P40925 | 2/20 | 0.48 |
| ▸ | MDH2 | P40926 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3556730 | 0.89 | HCAR2 (0.70) | HCAR2LMNAMAPTALDH1A1HIF1A | |
| SCHEMBL3552433 | 0.85 | ALDH1A1 (0.54) | HCAR2LMNAMAPTALDH1A1MAPK10 | |
| SCHEMBL3554671 | 0.83 | ALDH1A1 (0.62) | HCAR2LMNAMAPTALDH1A1MAPK10 | |
| SCHEMBL3557253 | 0.83 | ALDH1A1 (0.57) | LMNAMAPTALDH1A1MAPK10TSHR | |
| SCHEMBL3552451 | 0.82 | ALDH1A1 (0.51) | MAPTALDH1A1MAPK10TSHRHSD17B10 | |
| SCHEMBL3552623 | 0.81 | TSHR (0.53) | HCAR2LMNAMAPTALDH1A1MAPK10 | |
| SCHEMBL3556557 | 0.81 | TP53 (0.55) | LMNAMAPTALDH1A1MAPK10TSHR | |
| SCHEMBL3552717 | 0.80 | MAPT (0.48) | MAPTALDH1A1MAPK10TSHRHSD17B10 | |
| SCHEMBL3559758 | 0.80 | GAA (0.53) | LMNAMAPTALDH1A1MAPK10TSHR | |
| SCHEMBL420665 | 0.79 | HCAR2 (0.60) | HCAR2LMNAMAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732452-B2 | Thiophene derivatives which are HM74A agonists | HOFFMANN-LA ROCHE INC. (US) | 2010-06-08 | — | — | US | disclosed |
| US-20070161650-A1 | Novel thiophene derivatives which are HM74A agonists | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-12 | — | — | US | disclosed |
| US-20070072873-A1 | Novel thiophene derivatives which are HM74A agonists | HOFFMANN-LA ROCHE INC. | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072873-A1 | Novel thiophene derivatives which are HM74A agonists | GPR84, GPR174, MRGPRX1 | HCAR2 121/4885LMNA 4064/4885MAPT 4815/4885 |
| US-20070161650-A1 | Novel thiophene derivatives which are HM74A agonists | GPR84, GPR174, MRGPRX1 | HCAR2 121/4885LMNA 4064/4885MAPT 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.