Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.44 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.44 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513587 | 0.97 | — | — | |
| Ethane SCHEMBL28162037 | 0.92 | APEX1 (0.57) | APEX1LMNAEGLN1ALKBH5SUCNR1 | |
| Acetic Acid SCHEMBL10800063 | 0.90 | APEX1 (0.50) | APEX1LMNAEGLN1ALKBH5SUCNR1 | |
| Adipic Acid SCHEMBL10904206 | 0.89 | LMNA (0.58) | APEX1LMNAPDE4ABLMSLC22A6 | |
| Mercaptopropionic Acid SCHEMBL6689886 | 0.85 | PTGS1 (0.52) | APEX1LMNAEGLN1ALKBH5SUCNR1 | |
| SCHEMBL5022360 | 0.83 | LMNA (0.50) | APEX1LMNAEGLN1ALKBH5SUCNR1 | |
| Methacrylic Acid SCHEMBL1881169 | 0.81 | APEX1 (0.46) | APEX1LMNAEGLN1ALKBH5SUCNR1 | |
| SCHEMBL513001 | 0.80 | LMNA (0.53) | APEX1LMNAEGLN1ALKBH5SUCNR1 | |
| SCHEMBL7098500 | 0.79 | TSHR (0.57) | LMNAPDE4ASLC22A6TSHRNFKB1 | |
| SCHEMBL16719244 | 0.79 | TSHR (0.57) | LMNAPDE4ASLC22A6TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662854-B2 | HIF hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2010-02-16 | — | — | US | disclosed |
| US-7638295-B2 | Identifying agent which modulates 2-oxoglutarate dependent oxygenase; ankyrin substrate; hypoxia-inducible factor; thalassemia | ISIS INNOVATION LIMITED (GB) | 2009-12-29 | — | — | US | disclosed |
| EP-2065366-A2 | HIF hydroxylase inhibitors | ISIS Innovation Limited (GB) | 2009-06-03 | — | — | EP | disclosed |
| EP-1485347-B1 | HIF HYDROXYLASE INHIBITORS FOR USE IN THE TREATMENT OF ANAEMIA | ISIS INNOVATION (GB) | 2009-04-29 | — | — | EP | disclosed |
| US-20080227848-A1 | Assays | ISIS INNOVATION LIMITED (GB) | 2008-09-18 | — | — | US | disclosed |
| EP-1466927-B1 | PROCESS FOR PRODUCTION OF CARBOXYLIC ACID POLYMERS | KAO CORP (JP) | 2007-03-28 | — | — | EP | disclosed |
| US-20070066576-A1 | HIF hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2007-03-22 | — | — | US | disclosed |
| EP-1733030-A2 | ASSAYS FOR IDENTIFYING MODULATORS OF THE HYDROXYLATION OF ANKYRIN REPEAT PROTEINS BY 2-OXOGLUTARATE DEPENDENT OXYGENASE AND METHODS OF USING THE SAME | ISIS INNOVATION LIMITED (GB) | 2006-12-20 | — | — | EP | disclosed |
| US-20050227948-A1 | Hif hydroxylase inhibitors | ISIS INNOVATION LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
| WO-2005093411-A2 | ASSAYS FOR IDENTIFYING MODULATORS OF THE HYDROXYLATION OF ANKYRIN REPEAT PROTEINS BY 2-OXOGLUTARATE DEPENDENT OXIGENASE AND METHODS OF USING THE SAME | ISIS INNOVATION LIMITED (GB) | 2005-10-06 | — | — | WO | disclosed |
| EP-1485347-A2 | HIF HYDROXYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2004-12-15 | — | — | EP | disclosed |
| EP-1466927-A1 | PROCESS FOR PRODUCTION OF CARBOXYLIC ACID POLYMERS | Kao Corporation (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003080566-A2 | HIF HYDROXYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227948-A1 | Hif hydroxylase inhibitors | HIF1AN, HIF1A, EGLN3 | APEX1 1504/4885LMNA 3704/4885EGLN1 5/4885 |
| US-20070066576-A1 | HIF hydroxylase inhibitors | HIF1AN, HIF1A, EGLN3 | APEX1 1504/4885LMNA 3704/4885EGLN1 5/4885 |
| US-20080227848-A1 | Assays | OGDH, HOGA1, OXGR1 | APEX1 137/4885LMNA 2834/4885EGLN1 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.