HOGA1

4-hydroxy-2-oxoglutarate aldolase, mitochondrial · Q86XE5 · HOGA1 on Sugi Atlas →

523 patent compounds predicted against HOGA1, 362 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL12647033	0.51	15/20
SCHEMBL15629991	0.82	6/20
SCHEMBL12965152	0.66	6/20
SCHEMBL19186529	0.59	6/20
SCHEMBL19186242	0.53	6/20
SCHEMBL19186236	0.51	6/20
SCHEMBL19186284	0.46	6/20
SCHEMBL12969610	0.75	5/20
SCHEMBL12965068	0.73	5/20
SCHEMBL19186132	0.73	5/20
SCHEMBL12818891	0.65	5/20
Hydrochloric Acid (SCHEMBL15611799)	0.63	5/20
Hydrochloric Acid (SCHEMBL15611800)	0.63	5/20
SCHEMBL12819255	0.61	5/20
SCHEMBL12819528	0.61	5/20
SCHEMBL12818062	0.60	5/20
Hydrochloric Acid (SCHEMBL15611196)	0.60	5/20
Hydrochloric Acid (SCHEMBL15611197)	0.60	5/20
Hydrochloric Acid (SCHEMBL15611605)	0.60	5/20
Hydrochloric Acid (SCHEMBL15611609)	0.60	5/20

Clinical trials — most relevant to HOGA1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:	PHASE3	ACTIVE_NOT_RECRUITING
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Prevention of Acute Myocardial Injury by Trimetazidine in Patients Hospitalized for COVID-19	PHASE2	UNKNOWN
EPI-743 for Metabolism or Mitochondrial Disorders	PHASE1/PHASE2	COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)	PHASE1/PHASE2	NOT_YET_RECRUITING
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis	PHASE2	COMPLETED
In Vivo Assessment of Cellular Metabolism in Humans	PHASE1	COMPLETED
Anaplerotic Therapy in Propionic Acidemia	PHASE1	COMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy	nan	UNKNOWN
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Mitochondrial Assessment in Critical Ill Patients in Intensive Care	nan	NOT_YET_RECRUITING
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)	nan	NOT_YET_RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Evaluation of Hydroxymethylbutyrate Supplementation in Lung Transplant Candidates Receiving Pulmonary Rehabilitation	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
18F-FDG PET in HCC Patients Candidate to Treatment With Sorafenib	nan	COMPLETED
Alpha-Ketoglutarate and Abdominal Aortic Aneurysm Progression and Rupture	nan	RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Impact Of Intermittent And Water-Only Fasting On Gene Expression And Tumor Markers In Breast Cancer	nan	ACTIVE_NOT_RECRUITING
Longitudinal Study of Mitochondrial Hepatopathies	nan	SUSPENDED
Determine the Frequency of Variants in the GBA/PSAP Genes in Patients With MM or MGUS	nan	RECRUITING
Pattern of Metabolic Causes of Neonatal Hypoglycemia	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a HOGA1 binder may also engage these)

Protein	Name	Similarity
Q9DCU9	—	1.000	Q9DCU9 →
Q5M8W9	—	1.000	Q5M8W9 →
Q5XGL6	—	1.000	Q5XGL6 →
Q0P5I5	—	0.997	Q0P5I5 →
Q6NY77	—	0.996	Q6NY77 →
P97519	—	0.987	P97519 →
Q5M905	—	0.987	Q5M905 →
P35914	—	0.984	P35914 →
Q29RY9	—	0.984	Q29RY9 →
P38060	—	0.983	P38060 →
Q5XGL8	—	0.982	Q5XGL8 →
Q29448	—	0.982	Q29448 →
Q8TB37	—	0.981	Q8TB37 →
P13228	—	0.980	P13228 →
O82357	—	0.980	O82357 →
B7PBI5	—	0.980	B7PBI5 →
Q01637	—	0.980	Q01637 →
Q9R061	—	0.980	Q9R061 →
Q9AXB0	—	0.980	Q9AXB0 →
Q9DCJ9	—	0.980	Q9DCJ9 →
P11725	—	0.980	P11725 →
Q9M315	—	0.980	Q9M315 →
O49290	—	0.979	O49290 →
Q7V4M4	—	0.979	Q7V4M4 →
PKLR	Pyruvate kinase PKLR	0.979	landscape →
Q9I2A0	—	0.979	Q9I2A0 →
Q5R9E1	—	0.979	Q5R9E1 →
F8WQN2	—	0.979	F8WQN2 →
Q5ZKD4	—	0.979	Q5ZKD4 →
P12928	—	0.979	P12928 →