Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 7/20 | 0.68 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.68 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.68 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17440420 | 0.93 | CHRNB2 (0.58) | CHRNB4CHRNA3CHRNB2CHRNA4BCHE | |
| SCHEMBL17440417 | 0.93 | CHRNB2 (0.58) | CHRNB4CHRNA3CHRNB2CHRNA4BCHE | |
| SCHEMBL28750100 | 0.88 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4KDM4E | |
| SCHEMBL29132428 | 0.85 | BCHE (0.70) | KDM4EBCHEMAOB | |
| SCHEMBL29132426 | 0.85 | BCHE (0.70) | KDM4EBCHEMAOB | |
| SCHEMBL27752879 | 0.82 | CHRNB2 (0.61) | CHRNB4CHRNA3CHRNB2CHRNA4KDM4E | |
| Hydrochloric Acid SCHEMBL27454368 | 0.79 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4KDM4E | |
| SCHEMBL7005697 | 0.78 | KDM4E (0.75) | CHRNB4CHRNA3CHRNB2CHRNA4KDM4E | |
| SCHEMBL3401970 | 0.77 | BCHE (0.61) | KMT2ABCHEMAOB | |
| SCHEMBL28412274 | 0.77 | BCHE (0.58) | BCHEMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750155-B2 | Pyrazinyl hydroxyacrylamide compounds having an inhibitory effect on the activity of histone deacetylase | ASTELLAS PHARMA INC. (JP) | 2010-07-06 | — | — | US | disclosed |