Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3565220 | 1.00 | DRD2 (0.50) | DRD2SIGMAR1GRIN1GRIN2BPARP1 | |
| SCHEMBL3553756 | 0.87 | HTR2A (0.55) | DRD2SIGMAR1GRIN1GRIN2BHTR2A | |
| SCHEMBL3553758 | 0.87 | HTR2A (0.55) | DRD2SIGMAR1GRIN1GRIN2BHTR2A | |
| SCHEMBL3560321 | 0.86 | HTR2A (0.54) | DRD2SIGMAR1GRIN1GRIN2BPARP1 | |
| SCHEMBL3560318 | 0.86 | HTR2A (0.54) | DRD2SIGMAR1GRIN1GRIN2BPARP1 | |
| SCHEMBL3557100 | 0.84 | DRD2 (0.48) | DRD2SIGMAR1GRIN1GRIN2BPARP1 | |
| SCHEMBL3551996 | 0.83 | HTR2A (0.56) | DRD2SIGMAR1GRIN1GRIN2BPARP1 | |
| SCHEMBL3557068 | 0.83 | HTR2A (0.56) | DRD2HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL3557066 | 0.83 | HTR2A (0.56) | DRD2HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL3551992 | 0.83 | HTR2A (0.56) | DRD2SIGMAR1GRIN1GRIN2BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675859-B1 | MODULATORS OF SEROTONIN RECEPTORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-05 | — | — | EP | disclosed |
| US-7812024-B2 | Modulators of serotonin receptors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-10-12 | — | — | US | disclosed |
| US-20070213337-A1 | MODULATORS OF SEROTONIN RECEPTORS | BRISTOL-MYERS SQUIBB COMPANY | 2007-09-13 | — | — | US | disclosed |
| US-7244843-B2 | Modulators of serotonin receptors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| US-20050080074-A1 | Modulators of serotonin receptors | BRISTOL-MYERS SQUIBB COMPANY | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213337-A1 | MODULATORS OF SEROTONIN RECEPTORS | HTR5A, HTR1A, HTR2A | DRD2 47/4885SIGMAR1 249/4885GRIN1 184/4885 |
| US-20050080074-A1 | Modulators of serotonin receptors | HTR5A, HTR1A, HTR2B | DRD2 45/4885SIGMAR1 260/4885GRIN1 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.