Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | MET | P08581 | 4/20 | 0.36 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2768454 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2TP53METKITKDR | |
| SCHEMBL3560647 | 0.83 | KCNA5 (0.36) | SMN1; SMN2SGMS2KCNA5 | |
| SCHEMBL3565420 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2TP53METKITKDR | |
| SCHEMBL2767552 | 0.74 | KCNA5 (0.36) | METSGMS2KCNA5 | |
| SCHEMBL2439933 | 0.73 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL2771072 | 0.72 | ALDH1A1 (0.31) | SMN1; SMN2AURKBKCNA5NPC1RAB9A | |
| SCHEMBL2438162 | 0.70 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53AURKBNPC1RAB9A | |
| SCHEMBL2768450 | 0.70 | MEN1 (0.44) | SMN1; SMN2TP53METKITKDR | |
| SCHEMBL2437970 | 0.68 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53AURKBNPC1RAB9A | |
| SCHEMBL2770485 | 0.67 | SMN1; SMN2 (0.46) | SMN1; SMN2TP53EPHX2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696238-B2 | Substituted benzo[d]isoxazol-3-yl amine compounds as analgesics | GRUENENTHAL GMBH (DE) | 2010-04-13 | — | — | US | disclosed |
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | GRUENENTHAL GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176915-A1 | Substituted Benzo[d]isoxazol-3-yl Amine Compounds as Analgesics | KCNQ1, KCNQ2, KCNQ3 | SMN1; SMN2 1349/4885TP53 4784/4885MET 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.