Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CPT1A | P50416 | 4/20 | 0.43 |
| ▸ | CPT2 | P23786 | 3/20 | 0.43 |
| ▸ | CPT1B | Q92523 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19643771 | 0.76 | HTR6 (0.45) | HTR6MEN1KMT2AMAPT | |
| SCHEMBL23498074 | 0.71 | ALDH1A1 (0.68) | MEN1KMT2AALDH1A1AKR1C3AKR1C1 | |
| SCHEMBL7237249 | 0.71 | HCRTR1 (0.54) | MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL7237244 | 0.71 | HCRTR1 (0.54) | MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL22566212 | 0.70 | MAPT (0.46) | MMP2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2706446 | 0.70 | HCRTR1 (0.61) | MEN1KMT2AALDH1A1 | |
| SCHEMBL2706441 | 0.70 | HCRTR1 (0.61) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5474250 | 0.70 | HTR6 (0.45) | HTR6MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL27440114 | 0.69 | LMNA (0.47) | KCNA3MMP2MEN1KMT2AALDH1A1 | |
| SCHEMBL2906296 | 0.68 | AKR1C3 (0.67) | AKR1C3AKR1C1MAPTCPT1ACPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926711-B1 | NOVEL HETEROBICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF LIVER CARNITINE PALMITOYL TRANSFERASE | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |
| US-7713996-B2 | Indolyl derivatives which are L-CPT1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2010-05-11 | — | — | US | disclosed |
| US-20070060567-A1 | Novel indolyl derivatives which are L-CPT1 inhibitors | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060567-A1 | Novel indolyl derivatives which are L-CPT1 inhibitors | CPT1A, CPT1B, CPT2 | KCNA3 4175/4885HTR6 1467/4885MMP2 2739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.