Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.75 |
| ▸ | HTR2C | P28335 | 11/20 | 0.75 |
| ▸ | HTR7 | P34969 | 5/20 | 0.69 |
| ▸ | DRD2 | P14416 | 2/20 | 0.69 |
| ▸ | HTR2B | P41595 | 3/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | HTR1D | P28221 | 2/20 | 0.64 |
| ▸ | HTR1B | P28222 | 2/20 | 0.64 |
| ▸ | HTR1E | P28566 | 2/20 | 0.64 |
| ▸ | HTR5A | P47898 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | HTR3A | P46098 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.62 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765058 | 0.87 | HTR7 (0.72) | HTR2AHTR2CHTR7DRD2HTR2B | |
| SCHEMBL3568931 | 0.85 | HTR2A (0.81) | HTR2AHTR2CHTR7DRD2 | |
| SCHEMBL764888 | 0.85 | HTR2B (0.72) | HTR2AHTR2CHTR7DRD2HTR2B | |
| SCHEMBL763632 | 0.83 | HTR2A (1.00) | HTR2AHTR2CHTR7DRD2HTR2B | |
| SCHEMBL763432 | 0.82 | HTR2A (0.77) | HTR2AHTR2CHTR7HTR2BHTR1A | |
| SCHEMBL3568230 | 0.82 | HTR7 (1.00) | HTR2AHTR2CHTR7DRD2MAPKAPK2 | |
| SCHEMBL1520425 | 0.82 | HTR2C (0.78) | HTR2AHTR2CHTR7HTR2BMAPKAPK2 | |
| SCHEMBL764196 | 0.81 | HTR7 (0.61) | HTR2AHTR2CHTR7DRD2HTR2B | |
| SCHEMBL763500 | 0.79 | PRMT5 (0.65) | HTR2AHTR2CHTR7DRD2HTR2B | |
| SCHEMBL14043228 | 0.79 | HTR7 (0.71) | HTR2AHTR2CHTR7DRD2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855295-B2 | Tetrahydrocarboline compounds as anticancer agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855295-B2 | Tetrahydrocarboline compounds as anticancer agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855295-B2 | Tetrahydrocarboline compounds as anticancer agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20050215580-A1 | Tetrahydrocarboline compounds as anticancer agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215580-A1 | Tetrahydrocarboline compounds as anticancer agents | MTHFD1, BAD, DHFR | HTR2A 1168/4885HTR2C 421/4885HTR7 434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.