Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 11/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561933 | 0.86 | SLC6A2 (0.64) | HTR6SLC6A2METHTR2A | |
| Hydrochloric Acid SCHEMBL3574163 | 0.85 | SLC6A2 (0.63) | HTR6SLC6A2METHTR2A | |
| SCHEMBL4686357 | 0.83 | HTR6 (0.52) | HTR6SLC6A2METHTR2AHTR2C | |
| SCHEMBL3574946 | 0.83 | SLC6A2 (0.68) | HTR6SLC6A2METHTR2AHTR2C | |
| SCHEMBL3568655 | 0.83 | SLC6A2 (0.67) | HTR6SLC6A2METHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL3565513 | 0.82 | SLC6A2 (0.65) | HTR6SLC6A2METHTR2AHTR2C | |
| SCHEMBL13544520 | 0.81 | HTR6 (0.48) | HTR6SLC6A2METHTR2AHTR2C | |
| SCHEMBL3570695 | 0.81 | SLC6A2 (0.68) | HTR6SLC6A2HTR2AHTR2CKCNH2 | |
| SCHEMBL3564086 | 0.81 | SLC6A2 (0.57) | HTR6SLC6A2METHTR2A | |
| SCHEMBL3567470 | 0.81 | SLC6A2 (0.70) | HTR6SLC6A2METHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645752-B2 | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors | WYETH LLC (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645752-B2 | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors | WYETH LLC (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645752-B2 | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors | WYETH LLC (US) | 2010-01-12 | — | — | US | disclosed |
| CN-101370775-A | Sulfonyl-substituted 1H-indoles as 5-hydroxytryptamine receptor ligands | WYETH CORP (US) | 2009-02-18 | — | — | CN | disclosed |
| EP-1973876-A2 | SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS | Wyeth (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20070203120-A1 | Sulfonyl Substituted 1H-Indoles as Ligands for the 5-Hydroxytryptamine Receptors | WYETH (US) | 2007-08-30 | — | — | US | disclosed |
| US-20070203120-A1 | Sulfonyl Substituted 1H-Indoles as Ligands for the 5-Hydroxytryptamine Receptors | WYETH (US) | 2007-08-30 | — | — | US | disclosed |
| US-20070203120-A1 | Sulfonyl Substituted 1H-Indoles as Ligands for the 5-Hydroxytryptamine Receptors | WYETH (US) | 2007-08-30 | — | — | US | disclosed |
| WO-2007084841-A2 | SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS | WYETH (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007084841-A2 | SULFONYL SUBSTITUTED 1H-INDOLES AS LIGANDS FOR THE 5-HYDROXYTRYPTAMINE RECEPTORS | WYETH (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203120-A1 | Sulfonyl Substituted 1H-Indoles as Ligands for the 5-Hydroxytryptamine Receptors | HTR5A, HTR2C, HTR2A | HTR6 6/4885SLC6A2 20/4885MET 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.