Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | LAP3 | P28838 | 3/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3562176 | 1.00 | CTRB1 (0.43) | CTRB1MTNR1AMTNR1BMMP2LAP3 | |
| SCHEMBL3559808 | 0.91 | MTNR1A (0.41) | CTRB1MTNR1AMTNR1BMMP2LAP3 | |
| SCHEMBL1011206 | 0.85 | MTNR1A (0.60) | CTRB1MTNR1AMTNR1BCYP3A4 | |
| SCHEMBL3559900 | 0.81 | MTNR1A (0.43) | MTNR1AMTNR1BMMP2CYP3A4HDAC1 | |
| SCHEMBL3559731 | 0.81 | MTNR1A (0.42) | MTNR1AMTNR1BMMP2CYP3A4 | |
| SCHEMBL4991230 | 0.76 | L3MBTL1 (0.50) | MTNR1AMTNR1B | |
| SCHEMBL3563505 | 0.76 | MIF (0.43) | MTNR1AMTNR1B | |
| SCHEMBL15547346 | 0.76 | MTNR1A (0.43) | CTRB1MTNR1AMTNR1BCYP3A4 | |
| SCHEMBL1430902 | 0.76 | MIF (0.56) | MTNR1AMTNR1B | |
| SCHEMBL5884516 | 0.76 | MTNR1A (0.41) | MTNR1AMTNR1BCYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825256-B2 | Inducible nitric oxide synthase dimerization inhibitors | KALYPSYS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |