Indene

Indene

SCHEMBL357035

C1=Cc2ccccc2C1.C=Cc1ccccc1C

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
ALDH1A1 P00352 3/20 0.36
TSHR P16473 1/20 0.36
NPC1 O15118 1/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
NFKB1 P19838 1/20 0.33
RAB9A P51151 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PARP1 P09874 1/20 0.33
ACHE P22303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indene SCHEMBL8048473 0.93 ALDH1A1 (0.39) CYP2D6CYP2C19CA1CA2ALDH1A1
Indene SCHEMBL29183448 0.88 CA1 (0.43) CYP2D6CYP2C19CA1CA2ALDH1A1
Indene SCHEMBL10603166 0.88 CYP2D6 (0.57) CYP2D6CYP2C19CA1CA2
Indene SCHEMBL10700684 0.82 CYP2D6 (0.39) CYP2D6CYP2C19ALDH1A1MAPT
Indene SCHEMBL546792 0.81 CYP2D6 (0.39) CYP2D6CYP2C19CA1CA2ALDH1A1
Indene SCHEMBL15021242 0.79 CA1 (0.47) CYP2D6CYP2C19CA1CA2PARP1
Indene SCHEMBL15048613 0.78 CYP2C19 (0.39) CYP2D6CYP2C19CA1CA2MAPT
Indene SCHEMBL8617 0.76
Indene SCHEMBL8336138 0.76 CA1 (0.55) CYP2D6CYP2C19CA1CA2TSHR
Indene SCHEMBL29350094 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0544672-A1 HOT MELT MOISTURE-CURE POLYURETHANE ADHESIVE. FULLER H B LICENSING FINANC (US) 1993-06-09 EP claimed
WO-1991015530-A1 HOT MELT MOISTURE-CURE POLYURETHANE ADHESIVE H.B. FULLER LICENSING & FINANCING INC. (US) 1991-10-17 WO claimed
CN-106574081-B Pneumatic tire 住友橡胶工业株式会社 2019-11-15 CN disclosed
CN-103946299-B Rubber composition and pneumatic tire 住友橡胶工业株式会社 2018-10-09 CN disclosed
CN-103946302-B Rubber composition and pneumatic tire 住友橡胶工业株式会社 2018-05-15 CN disclosed
EP-2772514-B1 RUBBER COMPOSITION, AND PNEUMATIC TIRE SUMITOMO RUBBER IND (JP) 2017-08-16 EP disclosed
CN-106574081-A Pneumatic tire 住友橡胶工业株式会社 2017-04-19 CN disclosed
US-9428641-B2 Rubber composition, and pneumatic tire SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2016-08-30 US disclosed
EP-2749594-B1 RUBBER COMPOSITION AND STUDLESS TIRE SUMITOMO RUBBER IND (JP) 2016-06-08 EP disclosed
EP-2772511-B1 RUBBER COMPOSITION, AND PNEUMATIC TIRE SUMITOMO RUBBER IND (JP) 2016-06-08 EP disclosed
US-9290644-B2 Rubber composition, and pneumatic tire SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2016-03-22 US disclosed
US-20140256847-A1 RUBBER COMPOSITION, AND PNEUMATIC TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2014-09-11 US disclosed
EP-2772511-A1 RUBBER COMPOSITION, AND PNEUMATIC TIRE Sumitomo Rubber Industries, Ltd. (JP) 2014-09-03 EP disclosed
EP-2772514-A1 RUBBER COMPOSITION, AND PNEUMATIC TIRE Sumitomo Rubber Industries, Ltd. (JP) 2014-09-03 EP disclosed
US-20140213693-A1 RUBBER COMPOSITION AND STUDLESS TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2014-07-31 US disclosed
EP-2749594-A1 RUBBER COMPOSITION AND STUDLESS TIRE Sumitomo Rubber Industries, Ltd. (JP) 2014-07-02 EP disclosed
US-20120016056-A1 RUBBER COMPOSITION FOR TREAD AND PNEUMATIC TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2012-01-19 US disclosed
EP-0292153-A2 Polyphenylene ether resin composition MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-11-23 EP disclosed
US-4636540-A ADSORPTION ATLANTIC RICHFIELD COMPANY (US) 1987-01-13 US disclosed
US-4587330-A TREATMENT WITH BORIC ACID, FILTRATION ATLANTIC RICHFIELD COMPANY (US) 1986-05-06 US disclosed