Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 19/20 | 0.77 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3564858 | 0.92 | KIF11 (0.76) | KIF11ABCB1ABCG2 | |
| SCHEMBL3571009 | 0.89 | KIF11 (0.83) | KIF11 | |
| SCHEMBL3575171 | 0.88 | KIF11 (0.78) | KIF11ABCG2 | |
| SCHEMBL3571887 | 0.87 | KIF11 (1.00) | KIF11 | |
| SCHEMBL3574607 | 0.87 | KIF11 (0.86) | KIF11 | |
| SCHEMBL3576798 | 0.87 | KIF11 (0.82) | KIF11 | |
| SCHEMBL12993669 | 0.86 | KIF11 (0.73) | KIF11 | |
| SCHEMBL3567366 | 0.85 | KIF11 (0.74) | KIF11ABCG2 | |
| SCHEMBL3579660 | 0.85 | KIF11 (0.82) | KIF11 | |
| SCHEMBL3574841 | 0.84 | KIF11 (0.75) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855295-B2 | Tetrahydrocarboline compounds as anticancer agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855295-B2 | Tetrahydrocarboline compounds as anticancer agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855295-B2 | Tetrahydrocarboline compounds as anticancer agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20050215580-A1 | Tetrahydrocarboline compounds as anticancer agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215580-A1 | Tetrahydrocarboline compounds as anticancer agents | MTHFD1, BAD, DHFR | KIF11 2735/4885ABCB1 70/4885ABCG2 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.