Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.62 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.59 |
| ▸ | TUBB | P07437 | 5/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.59 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.59 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.59 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.59 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.59 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27414286 | 0.84 | APP (0.62) | APPTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL33786 | 0.81 | TRPA1 (0.68) | APPTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL29778007 | 0.81 | TRPA1 (0.68) | APPTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL29955520 | 0.80 | ALDH1A1 (0.68) | APPTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL1324627 | 0.80 | ALDH1A1 (0.68) | APPTUBB1TUBB4ATUBBTUBA3C | |
| Methoxymethane SCHEMBL28668338 | 0.79 | TRPA1 (0.66) | APPTUBB1TUBB4ATUBBTUBA3C | |
| Ethylene SCHEMBL28209809 | 0.79 | TRPA1 (0.66) | APPTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL365142 | 0.78 | APP (0.71) | APPTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL30119825 | 0.78 | TRPA1 (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL165188 | 0.78 | TRPA1 (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180298026-A1 | Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators | HOFFMANN-LA ROCHE INC. | 2018-10-18 | — | — | US | disclosed |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | HOFFMANN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | HOFFMANN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | HOFFMANN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| EP-3252054-A1 | PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252054-A1 | PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2017-12-06 | — | — | EP | disclosed |
| EP-2593457-B1 | PYRAZOLO[1,5A]PYRIMIDINE AND THIENO[3,2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2017-08-23 | — | — | EP | disclosed |
| EP-2593457-B1 | PYRAZOLO[1,5A]PYRIMIDINE AND THIENO[3,2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2017-08-23 | — | — | EP | disclosed |
| US-20170027948-A1 | MACROCYCLIC COMPOUNDS AS ALK, FAK AND JAK2 INHIBITORS | CEPHALON, INC. | 2017-02-02 | — | — | US | disclosed |
| US-9487529-B2 | Macrocyclic compounds as ALK, FAK and JAK2 inhibitors | CEPHALON, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| EP-2686323-A1 | MACROCYCLIC COMPOUNDS AS ALK, FAK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2014-01-22 | — | — | EP | disclosed |
| WO-2013166037-A1 | NON-RETINOID ANTAGONISTS FOR TREATMENT OF EYE DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-11-07 | — | — | WO | disclosed |
| WO-2013107761-A1 | SUBSTITUTED TRIAZOLES AND THEIR USE FOR TREATMENT AND/OR PREVENTION NEUROLOGICAL AND PSYCHIATRIC DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-25 | — | — | WO | disclosed |
| EP-2593457-A1 | PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012125603-A1 | MACROCYCLIC COMPOUNDS AS ALK, FAK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-09-20 | — | — | WO | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | ARORA NIDHI (US) | 2012-01-19 | — | — | US | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023589-B2 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK4, IRAK1, IRAK2 | APP 3287/4885TUBB1 1918/4885TUBB4A 1471/4885 |
| US-20170027948-A1 | MACROCYCLIC COMPOUNDS AS ALK, FAK AND JAK2 INHIBITORS | JAK2, ALK, JAK1 | APP 4063/4885TUBB1 2203/4885TUBB4A 2541/4885 |
| US-20120015962-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | APP 3287/4885TUBB1 1918/4885TUBB4A 1471/4885 |
| US-20180298026-A1 | Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators | IRAK4, IRAK1, IRAK2 | APP 3287/4885TUBB1 1918/4885TUBB4A 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.