Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | GPR52 | Q9Y2T5 | 5/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576444 | 0.82 | GPR52 (0.50) | NR3C2RPS6KB1AURKAAURKBSIRT2 | |
| SCHEMBL1721830 | 0.81 | ALDH1A1 (0.52) | NR3C2RPS6KB1AURKAAURKBTAAR1 | |
| SCHEMBL2129712 | 0.80 | KDM4E (0.57) | NR3C2RPS6KB1SIRT2MEN1ALDH1A1 | |
| SCHEMBL3233027 | 0.79 | SIRT2 (0.54) | NR3C2RPS6KB1AURKAAURKBSIRT2 | |
| SCHEMBL2749287 | 0.77 | ALDH1A1 (0.55) | NR3C2RPS6KB1AURKAAURKBGPR52 | |
| SCHEMBL253705 | 0.75 | AURKA (0.47) | NR3C2RPS6KB1AURKAAURKBMAOB | |
| SCHEMBL30450224 | 0.75 | SYK (0.49) | SIRT2GPR52MAPK8LMNAHPGD | |
| SCHEMBL5178386 | 0.74 | PARP1 (0.58) | RPS6KB1AURKAAURKBMEN1ALDH1A1 | |
| SCHEMBL1971769 | 0.73 | SYK (0.55) | MEN1ALDH1A1LMNAKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6171278 | 0.73 | MAPK8 (0.52) | NR3C2RPS6KB1AURKAAURKBMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-20070219261-A1 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219261-A1 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | AADAT, AAAS, AADAC | NR3C2 2898/4885RPS6KB1 467/4885AURKA 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.