Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.52 |
| ▸ | AHR | P35869 | 3/20 | 0.50 |
| ▸ | CMA1 | P23946 | 2/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | TDP2 | O95551 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3194345 | 0.90 | SMYD3 (0.58) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL30760741 | 0.90 | SMYD3 (0.58) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL3581639 | 0.90 | TDP2 (0.55) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL3581228 | 0.89 | SMYD3 (0.55) | SMYD3AHRHDAC3 | |
| SCHEMBL3573881 | 0.89 | SMYD3 (0.55) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| Hydrochloric Acid SCHEMBL29528151 | 0.89 | SMYD3 (0.57) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL7679044 | 0.88 | SMYD3 (0.53) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL4874148 | 0.84 | SMYD3 (0.51) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL3578248 | 0.82 | SMYD3 (0.52) | SMYD3CRBNAHRCMA1EIF2AK2 | |
| SCHEMBL3578410 | 0.80 | CRBN (0.52) | SMYD3CRBNAHRCMA1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7749530-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2010-07-06 | — | — | US | disclosed |
| WO-2010075197-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-7692005-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20090208557-A1 | Kinase inhibitors | ALLERGAN, INC. | 2009-08-20 | — | — | US | disclosed |
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| US-20070032478-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-02-08 | — | — | US | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090208557-A1 | Kinase inhibitors | PTK2, MAP3K6, MAP3K20 | SMYD3 3186/4885CRBN 982/4885AHR 2818/4885 |
| US-20070032478-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | SMYD3 1968/4885CRBN 789/4885AHR 2478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.