Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | OGA | O60502 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790083 | 0.81 | OGA (0.52) | MAPK8MAPK9MAPK10OGAHTR7 | |
| SCHEMBL2883441 | 0.79 | OGA (0.53) | OGAHTR7MKNK1MKNK2ADRA2B | |
| SCHEMBL2881341 | 0.77 | OGA (0.46) | OGAHTR7MKNK1MKNK2ADRA2B | |
| SCHEMBL3574117 | 0.76 | MAPK10 (0.52) | MAPK8MAPK9MAPK10OGACNR2 | |
| SCHEMBL27514125 | 0.74 | ULK1 (0.41) | OGAHTR7MKNK1MKNK2ADRA2B | |
| SCHEMBL27570733 | 0.74 | MRGPRX1 (0.40) | OGAHTR7MKNK1MKNK2ADRA2B | |
| SCHEMBL28742511 | 0.74 | OGA (0.40) | OGAHTR7MKNK1MKNK2ADRA2B | |
| SCHEMBL27537476 | 0.74 | HTR7 (0.49) | OGACNR2HTR7ADRA2BADRA2C | |
| SCHEMBL27514461 | 0.74 | OGA (0.44) | OGAHTR7MKNK1MKNK2ADRA2B | |
| SCHEMBL2883059 | 0.74 | OGA (0.38) | OGAHTR7MKNK1MKNK2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855212-B2 | Pyridinyl acetonitriles | MERCK SERONO SA (CH) | 2010-12-21 | — | — | US | claimed |
| US-20070060594-A1 | Pyridinyl acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-03-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060594-A1 | Pyridinyl acetonitriles | GSK3B, GSK3A, MAPK3 | MAPK8 31/4885MAPK9 105/4885MAPK10 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.