SCHEMBL2790083

SCHEMBL2790083

N#CCc1ccnc(NCCc2cccnc2)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OGA O60502 3/20 0.52
MAPK8 P45983 2/20 0.52
MAPK9 P45984 2/20 0.52
MAPK10 P53779 2/20 0.52
MKNK1 Q9BUB5 3/20 0.51
MKNK2 Q9HBH9 3/20 0.51
CCNA2 P20248 2/20 0.44
CDK2 P24941 2/20 0.44
SGK1 O00141 1/20 0.44
ROCK2 O75116 1/20 0.44
RPS6KA5 O75582 1/20 0.44
RAF1 P04049 1/20 0.44
SRC P12931 1/20 0.44
BLK P51451 1/20 0.44
RPS6KA3 P51812 1/20 0.44
MAP2K6 P52564 1/20 0.44
CCNA1 P78396 1/20 0.44
MAPK14 Q16539 1/20 0.44
KDM4E B2RXH2 1/20 0.43
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2885608 0.88 HPGD (0.48) OGAMAPK10CDK2KDM4ECYP1A2
SCHEMBL2883441 0.87 OGA (0.53) OGAMKNK1MKNK2CCNA2CDK2
Pyridine SCHEMBL3574121 0.81 MAPK8 (0.39) OGAMAPK8MAPK9MAPK10MKNK1
SCHEMBL27537256 0.81 KDM4E (0.45) OGAKDM4ECYP3A4NOS3NOS1
SCHEMBL27514126 0.81 HDAC3 (0.46) OGAIGF1RNOS3NOS1NOS2
SCHEMBL2881341 0.80 OGA (0.46) OGAMKNK1MKNK2CCNA2CDK2
SCHEMBL27570733 0.80 MRGPRX1 (0.40) OGAMKNK1MKNK2CCNA2CDK2
SCHEMBL27537476 0.80 HTR7 (0.49) OGAADRA2BADRA2CSLC6A2HRH2
SCHEMBL28742511 0.80 OGA (0.40) OGAMKNK1MKNK2CCNA2CDK2
SCHEMBL27514125 0.80 ULK1 (0.41) OGAMKNK1MKNK2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190298799-A1 CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. 2019-10-03 US claimed
EP-1527070-B1 AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS MERCK SERONO SA (CH) 2013-01-09 EP claimed
JP-2005533066-A 2005-11-04 JP claimed
EP-1527070-A1 AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS Applied Research Systems ARS Holding N.V. (AN) 2005-05-04 EP claimed
WO-2003106455-A1 AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-12-24 WO claimed
EP-4709405-A2 FLUORESCEIN-LABELED NERVE TARGETING PEPTIDE FORMULATIONS AND RELATED METHODS Alume Biosciences, Inc. (US) 2026-03-18 EP disclosed
EP-4484952-A2 OPTIMIZED PEPTIDES FOR TARGETING HUMAN NERVES AND THEIR USE IN IMAGE GUIDED SURGERY, DIAGNOSTICS AND THERAPEUTIC DELIVERY The Regents of the University of California (US) 2025-01-01 EP disclosed
WO-2024233683-A2 FLUORESCEIN-LABELED NERVE TARGETING PEPTIDE FORMULATIONS AND RELATED METHODS ALUME BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed
EP-3661539-B1 OPTIMIZED PEPTIDES FOR TARGETING HUMAN NERVES AND THEIR USE IN IMAGE GUIDED SURGERY, DIAGNOSTICS AND THERAPEUTIC DELIVERY UNIV CALIFORNIA (US) 2024-10-09 EP disclosed
US-20240207422-A1 NERVE TARGETING PEPTIDE CONJUGATES AND METHODS OF USE ALUME BIOSCIENCES INC (US) 2024-06-27 US disclosed
US-20240207421-A1 NERVE TARGETING PEPTIDES AND METHODS OF USE ALUME BIOSCIENCES INC (US) 2024-06-27 US disclosed
US-20240124523-A1 OPTIMIZED PEPTIDES FOR TARGETING HUMAN NERVES AND THEIR USE IN IMAGE GUIDED SURGERY, DIAGNOSTICS AND THERAPEUTIC DELIVERY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2024-04-18 US disclosed
US-20100022661-A1 CONTROLLED RELEASE COMPOSITIONS FOR MODULATING FREE-RADICAL INDUCED DAMAGE AND METHODS OF USE THEREOF OTONOMY, INC. (US) 2010-01-28 US disclosed
WO-2010011605-A2 CONTROLLED-RELEASE OTIC STRUCTURE MODULATING AND INNATE IMMUNE SYSTEM MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-01-28 WO disclosed
WO-2010008995-A2 CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-01-21 WO disclosed
US-20100016218-A1 CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-01-21 US disclosed
US-20090297533-A1 CONTROLLED RELEASE IMMUNOMODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2009-12-03 US disclosed
EP-1676574-A2 Methods for promoting survival of transplanted tissues and cells Johnson & Johnson Vision Care, Inc. (US) 2006-07-05 EP disclosed
EP-1527070-A1 AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS Applied Research Systems ARS Holding N.V. (AN) 2005-05-04 EP disclosed
WO-2003106455-A1 AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2003-12-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016218-A1 CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS BAX, BCL2, AIFM1 OGA 1063/4885MAPK8 3909/4885MAPK9 4695/4885
US-20100022661-A1 CONTROLLED RELEASE COMPOSITIONS FOR MODULATING FREE-RADICAL INDUCED DAMAGE AND METHODS OF USE THEREOF OTC, ARG2, COX6A1 OGA 640/4885MAPK8 4426/4885MAPK9 4825/4885
US-20190298799-A1 CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS BAX, BCL2, AIFM1 OGA 1063/4885MAPK8 3909/4885MAPK9 4695/4885
US-20090297533-A1 CONTROLLED RELEASE IMMUNOMODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTC, CD74, TSLP OGA 1319/4885MAPK8 4739/4885MAPK9 4880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.