Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577122 | 0.91 | NLRP3 (0.42) | NLRP3SCN3ASLC2A1CCR3F2 | |
| SCHEMBL3582286 | 0.91 | NLRP3 (0.41) | NLRP3SCN3ASLC2A1CCR3F2 | |
| SCHEMBL3569645 | 0.88 | CCR9 (0.43) | NLRP3SLC2A1ALDH1A1KDM4EGLA | |
| SCHEMBL3572707 | 0.83 | CCR9 (0.42) | ALDH1A1KDM4EGLAGAALPAR1 | |
| SCHEMBL27750952 | 0.83 | NLRP3 (0.40) | NLRP3SCN3ASLC2A1CCR3F2 | |
| SCHEMBL3577563 | 0.83 | NLRP3 (0.42) | NLRP3SLC2A1CCR3ALDH1A1KDM4E | |
| SCHEMBL3586383 | 0.82 | NLRP3 (0.39) | NLRP3SLC2A1CCR3F2F10 | |
| SCHEMBL3576208 | 0.80 | NLRP3 (0.42) | NLRP3SLC2A1LPAR1LPAR2C5AR1 | |
| SCHEMBL3581908 | 0.79 | NLRP3 (0.41) | NLRP3SLC2A1LPAR1LPAR2C5AR1 | |
| SCHEMBL3580698 | 0.78 | C5AR1 (0.44) | ALDH1A1KDM4EGLAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |