Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CCR9 | P51686 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577159 | 0.92 | C5AR1 (0.42) | C5AR1LMNAUTS2RKDM4EALDH1A1 | |
| SCHEMBL3571491 | 0.92 | C5AR1 (0.42) | C5AR1LMNAUTS2RKDM4EALDH1A1 | |
| SCHEMBL3584396 | 0.91 | C5AR1 (0.44) | C5AR1LMNACNR1KDM4EALDH1A1 | |
| SCHEMBL3571528 | 0.87 | TP53 (0.41) | C5AR1LMNAKDM4EALDH1A1GLA | |
| SCHEMBL3586383 | 0.87 | NLRP3 (0.39) | C5AR1LMNAKDM4EALDH1A1GLA | |
| SCHEMBL3572707 | 0.87 | CCR9 (0.42) | C5AR1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3575609 | 0.87 | LMNA (0.43) | C5AR1LMNACNR1MEN1CYP1A2 | |
| SCHEMBL3586185 | 0.86 | LMNA (0.43) | C5AR1LMNACNR1GAAMEN1 | |
| SCHEMBL3585679 | 0.86 | LMNA (0.44) | C5AR1LMNACNR1GAAMEN1 | |
| SCHEMBL3584461 | 0.86 | LMNA (0.44) | C5AR1LMNACNR1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |