Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 3/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12993582 | 1.00 | ALOX5 (0.38) | ALOX5SCN1ASCN5ASCN8ADPP4 | |
| SCHEMBL3574764 | 1.00 | ALOX5 (0.38) | ALOX5SCN1ASCN5ASCN8ADPP4 | |
| SCHEMBL12993581 | 0.90 | CPS1 (0.40) | ALOX5SCN1ASCN5ASCN8AHRH3 | |
| SCHEMBL4662385 | 0.90 | CPS1 (0.40) | ALOX5SCN1ASCN5ASCN8AHRH3 | |
| SCHEMBL3586474 | 0.90 | CPS1 (0.40) | ALOX5SCN1ASCN5ASCN8AHRH3 | |
| SCHEMBL3586481 | 0.87 | MET (0.42) | HRH3MET | |
| SCHEMBL3586478 | 0.87 | MET (0.42) | HRH3MET | |
| SCHEMBL12102084 | 0.84 | GRM5 (0.46) | HRH3METSPHK2GRM5POLB | |
| SCHEMBL3276455 | 0.84 | GRM5 (0.46) | HRH3METSPHK2GRM5POLB | |
| SCHEMBL3276452 | 0.84 | GRM5 (0.46) | HRH3METSPHK2GRM5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846950-B2 | Histamine H3 receptor inhibitors, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2010-12-07 | — | — | US | claimed |
| EP-1805169-B1 | HISTAMINE H3 RECEPTOR INHIBITORS, THEIR PREPARATION AND THERAPEUTIC USES | LILLY CO ELI (US) | 2008-12-24 | — | — | EP | claimed |
| US-20080015235-A1 | Histamine H3 Receptor Inhibitors, Preparation and Therapeutic Uses | JESUDASON CYNTHIA D | 2008-01-17 | — | — | US | claimed |
| US-7846950-B2 | Histamine H3 receptor inhibitors, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2010-12-07 | — | — | US | disclosed |
| US-20080015235-A1 | Histamine H3 Receptor Inhibitors, Preparation and Therapeutic Uses | JESUDASON CYNTHIA D | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015235-A1 | Histamine H3 Receptor Inhibitors, Preparation and Therapeutic Uses | HRH3, HRH4, HCRTR1 | ALOX5 1625/4885SCN1A 966/4885SCN5A 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.