SCHEMBL4662385 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	CPS1	P31327	8/20	0.40

▸	ALOX5	P09917	1/20	0.40

▸	HRH3	Q9Y5N1	5/20	0.39

▸	KCNH2	Q12809	3/20	0.39

▸	CYP3A4	P08684	2/20	0.39

▸	PDE4B	Q07343	2/20	0.39

▸	MET	P08581	2/20	0.36

▸	PREP	P48147	1/20	0.35

▸	SCN1A	P35498	1/20	0.35

▸	SCN5A	Q14524	1/20	0.35

▸	SCN8A	Q9UQD0	1/20	0.35

▸	KMT2A	Q03164	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL12993581	1.00	CPS1 (0.40)	CPS1ALOX5HRH3KCNH2CYP3A4
SCHEMBL3586474	1.00	CPS1 (0.40)	CPS1ALOX5HRH3KCNH2CYP3A4
SCHEMBL3574764	0.90	ALOX5 (0.38)	ALOX5HRH3KCNH2CYP3A4PDE4B
SCHEMBL3574763	0.90	ALOX5 (0.38)	ALOX5HRH3KCNH2CYP3A4PDE4B
SCHEMBL12993582	0.90	ALOX5 (0.38)	ALOX5HRH3KCNH2CYP3A4PDE4B
SCHEMBL3578481	0.88	MET (0.45)	HRH3MET
SCHEMBL3578478	0.88	MET (0.45)	HRH3MET
SCHEMBL3587048	0.87	ALOX5 (0.39)	CPS1ALOX5HRH3KCNH2CYP3A4
SCHEMBL3587046	0.87	ALOX5 (0.39)	CPS1ALOX5HRH3KCNH2CYP3A4
SCHEMBL12993585	0.87	ALOX5 (0.39)	CPS1ALOX5HRH3KCNH2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1805169-B1	HISTAMINE H3 RECEPTOR INHIBITORS, THEIR PREPARATION AND THERAPEUTIC USES	LILLY CO ELI (US)	2008-12-24	—	—	EP	claimed