Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810124 | 0.95 | CLK4 (0.47) | CLK4DYRK1APIM1PIM3AURKB | |
| SCHEMBL6806567 | 0.91 | CHEK2 (0.42) | CLK4DYRK1APIM1PIM3AURKB | |
| SCHEMBL6805384 | 0.88 | CLK4 (0.44) | CLK4DYRK1APIM1PIM3AURKB | |
| SCHEMBL6809854 | 0.85 | PIM1 (0.60) | CLK4DYRK1APIM1PIM3AURKB | |
| SCHEMBL6806267 | 0.82 | HTR1A (0.43) | CLK4DYRK1APIM1PIM3AURKB | |
| SCHEMBL6809941 | 0.82 | PARP1 (0.48) | PIM1PIM3AURKBFLT3BRSK1 | |
| SCHEMBL6806139 | 0.81 | IKBKB (0.52) | CLK4DYRK1AAURKBCLK2LCK | |
| SCHEMBL6810121 | 0.81 | HTR1A (0.41) | CLK4DYRK1APIM1PIM3AURKB | |
| SCHEMBL6805803 | 0.81 | PARP1 (0.49) | PARP1LMNAMEN1MAPTKMT2A | |
| SCHEMBL6806306 | 0.81 | PARP1 (0.47) | PIM1PIM3AURKBCSF1RFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |