SCHEMBL357610

SCHEMBL357610

C#CCc1c(F)c(F)c(CO)c(F)c1F

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9340382 0.88 ALDH1A1 (0.30) ALDH1A1
SCHEMBL476668 0.84
SCHEMBL9766099 0.80 CA2 (0.36)
SCHEMBL10582414 0.80 POLB (0.30) POLB
SCHEMBL522934 0.78 POLB (0.33) POLB
SCHEMBL10583978 0.75 KDM4E (0.31) POLB
SCHEMBL14299618 0.75
SCHEMBL580614 0.75
SCHEMBL12629719 0.75
SCHEMBL536295 0.74 POLB (0.32) POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111533644-B Synthetic method of key intermediate 4-propargyl-2, 3,5, 6-tetrafluorobenzyl alcohol of fluorobenzyl insecticides 浙江工业大学 2022-12-09 CN claimed
CN-111533644-B Synthetic method of key intermediate 4-propargyl-2, 3,5, 6-tetrafluorobenzyl alcohol of fluorobenzyl insecticides 浙江工业大学 2022-12-09 CN disclosed
CN-111533644-B Synthetic method of key intermediate 4-propargyl-2, 3,5, 6-tetrafluorobenzyl alcohol of fluorobenzyl insecticides 浙江工业大学 2022-12-09 CN disclosed
CN-111533644-B Synthetic method of key intermediate 4-propargyl-2, 3,5, 6-tetrafluorobenzyl alcohol of fluorobenzyl insecticides 浙江工业大学 2022-12-09 CN disclosed
CN-111533644-A Synthetic method of key intermediate 4-propargyl-2, 3,5, 6-tetrafluorobenzyl alcohol of fluorobenzyl insecticides 浙江工业大学 2020-08-14 CN disclosed
CN-111533644-A Synthetic method of key intermediate 4-propargyl-2, 3,5, 6-tetrafluorobenzyl alcohol of fluorobenzyl insecticides 浙江工业大学 2020-08-14 CN disclosed
EP-1792889-B1 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL CO (JP) 2015-03-04 EP disclosed
CN-102365264-B Process for producing 3-(2-cyano-1-propenyl)-2,2- dimethylcyclopropanecarboxylic acid or salt thereof SUMITOMO CHEMICAL CO 2014-05-21 CN disclosed
EP-2418197-B1 PROCESS FOR PRODUCING 3-(2-CYANO-1-PROPENYL)-2,2- DIMETHYLCYCLOPROPANECARBOXYLIC ACID OR SALT THEREOF SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
EP-1547995-B1 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
US-5132469-A Insecticides, Miticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-07-21 US disclosed
WO-1992004317-A2 NOVEL IMIDATE INSECTICIDES ICI AMERICAS INC. (US) 1992-03-19 WO disclosed
US-5017606-A Insecticides, miticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-05-21 US disclosed
EP-0364116-A1 Insecticidal compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-04-18 EP disclosed
EP-0196156-B1 FLUOROBENZYL ESTERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-02-07 EP disclosed
US-4762835-A INSECTICIDES, MITICIDES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-08-09 US disclosed
EP-0271240-A2 Fluorobenzyl esters ZENECA LIMITED (GB) 1988-06-15 EP disclosed
EP-0227415-A2 Pyrimidine derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-07-01 EP disclosed
EP-0196156-A1 Fluorobenzyl esters IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-10-01 EP disclosed
CN-86101408-A The preparation of fluorobenzyl esters and application thereof 1986-09-17 CN disclosed