Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ESRRB | O95718 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | CCR9 | P51686 | 3/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581531 | 0.94 | C5AR1 (0.43) | SERPINE1C5AR1ESRRGLMNAHTT | |
| SCHEMBL2385645 | 0.90 | TP53 (0.42) | TP53MAPTESRRGSMN1; SMN2MCHR1 | |
| SCHEMBL3571600 | 0.87 | LMNA (0.42) | SERPINE1C5AR1LMNASMN1; SMN2CNR1 | |
| SCHEMBL3576208 | 0.86 | NLRP3 (0.42) | NLRP3C5AR1LMNACCR9LPAR1 | |
| SCHEMBL3587697 | 0.86 | C5AR1 (0.41) | NLRP3C5AR1LMNAF10HSP90AA1 | |
| SCHEMBL3586617 | 0.86 | C5AR1 (0.41) | NLRP3C5AR1LMNAF10HSP90AA1 | |
| SCHEMBL3584396 | 0.84 | C5AR1 (0.44) | SERPINE1C5AR1ESRRGLMNAHTT | |
| SCHEMBL3583813 | 0.84 | CNR1 (0.41) | C5AR1CNR1LPAR1LPAR5 | |
| SCHEMBL3569921 | 0.82 | SERPINE1 (0.47) | SERPINE1C5AR1ESRRGLMNAHTT | |
| SCHEMBL3577122 | 0.82 | NLRP3 (0.42) | NLRP3C5AR1F2F10F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |