Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573515 | 0.92 | C5AR1 (0.46) | TP53MAPTC5AR1RECQLOPRM1 | |
| SCHEMBL3582155 | 0.88 | F2 (0.42) | TP53MAPTC5AR1LPAR1LPAR5 | |
| SCHEMBL3577818 | 0.85 | LMNA (0.42) | MAPTC5AR1CYP2C19CDK8LPAR1 | |
| SCHEMBL12521115 | 0.82 | LPAR1 (0.40) | TP53MAPTC5AR1CYP2C19CDK8 | |
| SCHEMBL12520870 | 0.80 | C5AR1 (0.47) | TP53MAPTC5AR1OPRM1OPRD1 | |
| SCHEMBL12520941 | 0.80 | CENPE (0.40) | TP53MAPTC5AR1CYP2C19OPRM1 | |
| SCHEMBL12521114 | 0.77 | TACR1 (0.36) | TP53MAPTCYP2C19OPRM1OPRD1 | |
| SCHEMBL3574025 | 0.77 | C5AR1 (0.46) | TP53MAPTC5AR1CYP2C19RECQL | |
| SCHEMBL12520886 | 0.76 | KCNH2 (0.38) | CDK8CLK4LPAR1LPAR5RCE1 | |
| SCHEMBL3584423 | 0.76 | LPAR1 (0.43) | TP53MAPTC5AR1RECQLLPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |