Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | FADS1 | O60427 | 1/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574025 | 0.92 | C5AR1 (0.46) | LPAR1LPAR5C5AR1KDM4ERCE1 | |
| SCHEMBL3576810 | 0.91 | LMNA (0.42) | LPAR1LPAR5C5AR1SLC2A1KDM4E | |
| SCHEMBL3587845 | 0.88 | LPAR1 (0.42) | LPAR1LPAR5C5AR1SLC2A1LPAR2 | |
| SCHEMBL3589450 | 0.87 | RECQL (0.44) | LPAR1LPAR5C5AR1AOC3KDM4E | |
| SCHEMBL3581208 | 0.86 | LPAR1 (0.45) | LPAR1LPAR5C5AR1KDM4EKMT2A | |
| SCHEMBL3575564 | 0.84 | SERPINE1 (0.43) | LPAR1LPAR5C5AR1SLC2A1KDM4E | |
| SCHEMBL12521286 | 0.81 | LMNA (0.51) | LPAR1LPAR5C5AR1SLC2A1KMT2A | |
| SCHEMBL12521079 | 0.81 | LMNA (0.44) | LPAR1LPAR5C5AR1SLC2A1TAAR1 | |
| SCHEMBL3577818 | 0.81 | LMNA (0.42) | LPAR1LPAR5C5AR1SLC2A1KMT2A | |
| SCHEMBL12520951 | 0.81 | LMNA (0.43) | LPAR1LPAR5C5AR1SLC2A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |