Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.48 |
| ▸ | PARP1 | P09874 | 5/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587289 | 0.96 | AURKA (0.56) | AURKAAURKBCHEK2PARP1PARP2 | |
| SCHEMBL3579920 | 0.87 | AURKA (0.49) | AURKAAURKBCHEK2PARP1PARP2 | |
| SCHEMBL3582849 | 0.87 | AURKB (0.58) | AURKAAURKBCHEK2PARP1 | |
| SCHEMBL3582854 | 0.87 | AURKB (0.70) | AURKAAURKBCHEK2PARP1 | |
| SCHEMBL6806130 | 0.86 | AURKA (0.56) | AURKAAURKBPARP1PARP2TNKS | |
| SCHEMBL3576982 | 0.84 | AURKA (0.52) | AURKAAURKBCHEK2PARP1PARP2 | |
| SCHEMBL3582373 | 0.84 | PARP1 (0.49) | AURKAAURKBCHEK2PARP1PARP2 | |
| SCHEMBL3582282 | 0.84 | AURKB (0.61) | AURKAAURKBCHEK2PARP1 | |
| SCHEMBL3581194 | 0.84 | AURKA (0.49) | AURKAAURKBCHEK2PARP1TNKS | |
| SCHEMBL3574441 | 0.84 | AURKA (0.75) | AURKAAURKBCHEK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |