Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.75 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.75 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582854 | 0.96 | AURKB (0.70) | AURKAAURKBACHEDRD2DRD3 | |
| SCHEMBL3582282 | 0.91 | AURKB (0.61) | AURKAAURKBACHEDRD2DRD3 | |
| SCHEMBL3587289 | 0.88 | AURKA (0.56) | AURKAAURKBCHEK2PARP1 | |
| SCHEMBL3582849 | 0.87 | AURKB (0.58) | AURKAAURKBACHEDRD2DRD3 | |
| SCHEMBL3574435 | 0.85 | AURKB (1.00) | AURKAAURKBPARP1 | |
| SCHEMBL3580122 | 0.84 | AURKB (0.56) | AURKAAURKBACHECHEK2PARP1 | |
| SCHEMBL3577227 | 0.84 | AURKA (0.53) | AURKAAURKBCHEK2PARP1 | |
| SCHEMBL6804570 | 0.84 | AURKA (0.72) | AURKAAURKBDRD2DRD3CHEK2 | |
| SCHEMBL3576982 | 0.83 | AURKA (0.52) | AURKAAURKBACHECHEK2PARP1 | |
| SCHEMBL6029840 | 0.82 | AURKA (0.64) | AURKAAURKBDRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |