Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.46 |
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582282 | 0.96 | AURKB (0.61) | AURKBAURKAACHECHEK2PARP1 | |
| SCHEMBL3582854 | 0.92 | AURKB (0.70) | AURKBAURKAACHECHEK2PARP1 | |
| SCHEMBL3585487 | 0.88 | PARP1 (0.54) | AURKBAURKAACHECHEK2PARP1 | |
| SCHEMBL3574441 | 0.87 | AURKA (0.75) | AURKBAURKAACHECHEK2PARP1 | |
| SCHEMBL3577227 | 0.87 | AURKA (0.53) | AURKBAURKACHEK2PARP1 | |
| SCHEMBL6806887 | 0.87 | AURKA (0.60) | AURKBAURKAACHEPARP1KDR | |
| SCHEMBL3587289 | 0.85 | AURKA (0.56) | AURKBAURKACHEK2PARP1 | |
| SCHEMBL3582843 | 0.85 | AURKB (0.76) | AURKBAURKAACHEPARP1KDR | |
| SCHEMBL3579920 | 0.85 | AURKA (0.49) | AURKBAURKAACHECHEK2PARP1 | |
| SCHEMBL3580122 | 0.83 | AURKB (0.56) | AURKBAURKAACHECHEK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |