Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CCR9 | P51686 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581190 | 0.91 | TRPV1 (0.41) | TRPV1SERPINE1LPAR1LMNALPAR5 | |
| SCHEMBL3575570 | 0.91 | TRPV1 (0.42) | TRPV1SERPINE1LPAR1LMNALPAR5 | |
| SCHEMBL3576449 | 0.90 | LPAR1 (0.39) | TRPV1LPAR1LPAR5CYP3A4ATM | |
| SCHEMBL3580626 | 0.90 | LMNA (0.40) | SERPINE1LPAR1LMNALPAR5HPGD | |
| SCHEMBL3583799 | 0.88 | CNR1 (0.40) | TRPV1LPAR1LPAR5VNN1ATM | |
| SCHEMBL3581908 | 0.88 | NLRP3 (0.41) | TRPV1LPAR1LPAR5SLC2A1CYP3A4 | |
| SCHEMBL3577795 | 0.87 | LMNA (0.38) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3579168 | 0.85 | SLC2A1 (0.41) | TRPV1SERPINE1LPAR1LMNALPAR5 | |
| SCHEMBL3581174 | 0.85 | LMNA (0.37) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3577892 | 0.85 | SLC2A1 (0.40) | TRPV1SERPINE1LPAR1LMNALPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |